It has been commonly assumed that calcium, which normally serves important functions as a membrane stabilizer, metabolic regulator, and sec­ ond messenger, also can mediate anoxic and toxic cell death (Schanne et aI., 1979; Farber, 1981; Trump et aI., 1981). It is then postulated that when the plasma membrane becomes unduly permeable to calcium, the free cytosolic concentration (Ca2+) rises to ...

Goemans showed that any n points x1, . . . xn in d-dimensions satisfying l 2 2 triangle inequalities can be embedded into l1, with worst-case distortion at most √ d. We extend this to the case when the points are approximately low-dimensional, albeit with average distortion guarantees. More precisely, we give an l2-to-l1 embedding with average distortion at most the stable rank, sr (M), of the ...

To cite: Monigari N, Deshpande A, Vedartham V, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2013202937 DESCRIPTION We report the case of a 30-year-old, 2 weeks postpartum female, with a history of right temporal headache, intermittent, holocranial in nature, moderate intensity with associated nausea and vomiting when headache was severe. Symptoms were wo...

Reperfusion of ischemic tissue results in the generation of reactive oxygen species that contribute to tissue injury. The sources of reactive oxygen species in reperfused tissue are not fully characterized. We hypothesized that the small GTPase Rac1 mediates the oxidative burst in reperfused tissue and thereby contributes to reperfusion injury. In an in vivo model of mouse hepatic ischemia/repe...

This talk will review two case studies that examine the effectiveness of using Fuzzy Top Event Probability (FTEP) over the conventional approach. Case study one relates to flash vessel in an ammonia tank, while in case study two ,using fuzzy set theory, the FTEP has been estimated for the existing ammonia storage tank in a large fertilizer complex located in Mumbai, India. In addition, a new fo...

We have measured 21-cm absorption spectra in the direction of three southern pulsars, PSRs B0736–40, B1451–68 and B1641–45, in three separate epochs spread over 2.5 yr. We see no evidence for any changes in the absorption spectra over this time span in spite of good velocity resolution and sensitivity. Towards PSR B1641–45 we place an upper limit of 10 cm on the change in the column density of ...

A constitutive model for the elastic-plastic behavior of plastically compressible orthotropic materials is proposed based on an ellipsoidal yield surface with evolving ellipticity to accommodate non-uniform hardening or softening associated with stressing in different directions. The model incorporates rate-dependence arising from material rate-dependence and micro-inertial effects. The basic i...

Primary support for this research was provided by the Joseph M. Katz Graduate School of Business, University of Pittsburgh. Additional assistance was provided by the Shell Oil Corporation and the General Motors Corporation. We particularly want to thank Meera Buck of Shell Oil and Vincent Barabba and Michael Kusnic of General Motors and 170 other managers and researchers who contributed importa...

The micromechanical damage mechanics formulated by Ashby and Sammis, 1990, “The Damage Mechanics of Brittle Solids in Compression,” Pure Appl. Geophys., 133(3), pp. 489–521, and generalized by Deshpande and Evans 2008, “Inelastic Deformation and Energy Dissipation in Ceramics: A Mechanism-Based Constitutive Model,” J. Mech. Phys. Solids, 56(10), pp. 3077–3100. has been extended to allow for a m...

We report the linear optical absorption spectra of aluminum clusters Aln (n = 2-5) involving valence transitions, computed using the large-scale all-electron configuration interaction (CI) methodology. Several low-lying isomers of each cluster were considered, and their geometries were optimized at the coupled-cluster singles-doubles (CCSD) level of theory. With these optimized ground-state geo...