Background: Hemophilia B is an X-linked hereditary disorder of blood coagulation system which is caused by factor IX (FIX) deficiency. Factor IX is a plasma glycoprotein that participates in the coagulation process leading to the generation of fibrin. Replacement of factor IX with plasma-derived or recombinant factor IX is the conventional treatment for hemophilia B to raise the factor IX le...

Alzheimer’s disease (AD) is the most common cause of age-related neurodegeneration and cognitive decline. AD more commonly occurs in females than males, so it necessary to consider new treatments specifically targeting this population. The present study investigated protective effects Begacestat (γ-secretase inhibitor-953, GSI-953) bone marrow-derived mesenchymal stem cells (BM-MSCs) during pre...

The therapeutic methods for chronic hepatitis B are limited. The shortage of organ donors and hepatitis B virus (HBV) reinfection obstruct the clinical application of orthotopic liver transplantation (OLT). In the present study, adipose-derived mesenchymal stem cells (AD-MSCs) and bone marrow-derived mesenchymal stem cells (BM-MSCs) were isolated from chronic hepatitis B patients and characteri...

introduction : use of adipose-derived stem cells (adscs) is a suggested hypothesis to enhance the regeneration of bone defects. this technique is of particular interest since adscs are more easily accessible via a non-invasive harvesting technique compared to bone marrow stem cells (bmscs). this study sought to assess the efficacy of adsc implantation for regeneration of localized mandibular bo...

BACKGROUND In experimental models, bone marrow-derived mesenchymal stem cells (BM-MSCs) have the capacity to differentiate into hepatocytes and exhibit antifibrotic effects. However, there have been no studies in humans with alcoholic cirrhosis. AIM The aim of this study was to elucidate the antifibrotic effect of BM-MSCs in patients with alcoholic cirrhosis, as a phase II clinical trial. M...

Introduction Based on previous researches, dental pulp stem cells (DPSCs) are easily accessible with limited morbidity after collection. Their embryonic origin, from neural crests, explains their multipotency. DPSCs are primarily derived from the pulp tissues of the teeth.Objective: This study was undertaken to isolate, culture, and characterize two different third molar and first premolar hum...

background: hemophilia b is an x-linked hereditary disorder of blood coagulation system which is caused by factor ix (fix) deficiency. factor ix is a plasma glycoprotein that participates in the coagulation process leading to the generation of fibrin. replacement of factor ix with plasma-derived or recombinant factor ix is the conventional treatment for hemophilia b to raise the factor ix level...

Genetic constructs with promoters fused to reporter genes for simultaneous monitoring of cellular events have been the focus of attention in recent years. Adenoviral vectors, which have distinctive characteristics, have been used to monitor the differentiation of stem cells in vitro. In the present study, a modified adenoviral vector was constructed, containing a mouse, rat, and human general a...