Eighty five charts of patients whose diagnoses have changed at least once between 1977 and 1981 (unstable) were compared with another randomly chosen charts where diagnosis during the subsequent admissions remained unchanged (stable). Seventy six percent of the changes occurred from one to the other diagnostic category and remained so. Seventy three percent of Schizophrenics, 77.5% of Manics, 4...

The electroencephalographic (EEG) sleep of 20 anorexic patients, 10 bulimic patients, and 10 age-matched healthy controls was studied. In addition, six anorexic patients and six bulimic patients had a cholinergic rapid eye movement (REM) sleep induction test (RIT) performed with the cholinergic agent RS 86. The three samples showed no major differences in sleep patterns. The same held true when...

Abnormal time experience (ATE) in schizophrenia is a long-standing theme of phenomenological psychopathology. This is because temporality constitutes the bedrock of any experience and its integrity is fundamental for the sense of coherence and continuity of selfhood and personal identity. To characterize ATE in schizophrenia patients as compared to major depressives we interviewed, in a clinica...

Diisopropylfluorophosphonate (DFP) is a drug which has been made available for physiological and pharmacological investigation as a result of researches carried out on the alkylfluorophosphonates by McCombie and Saunders (1946) for the Ministry of Supply. The anticholinesterase action of these compounds was recognized in 1941 by Adrian, Feldberg, and Kilby (1947). Later, Mackworth and Webb (194...

Purpose: This study aims to investigate the emotional perspective of having Dyslexia, a specific learning difficulty that not only affects literacy but many aspects of an individual’s life, from childhood into adulthood. This paper investigates negative emotional coping which took place, which included self-harming with: alcohol, food, body injury, suicide thoughts and suicidal attempts. Method...

We previously reported a trend toward a higher mean nocturnal serum melatonin (MEL) concentration, based on 30-min blood sampling over 24 h, in 23 female definite endogenous depressive compared to 23 matched normal female control subjects, and no significant difference in 15 male depressives compared to their controls (Rubin et al., 1992). In both groups of patients vs. their controls, there al...

A very high prevalence of psychiatric morbidity among the persons attempting or committing suicide has been observed by several investigators (Barraclough et al, 1974; Beck et al, 1990; Drake et al, 1985). In a study of attempted suicide Morgan et al. (1975) reported neurotic depression in 52%, personality disorder in 29% functional psychosis in 12% and alcohol addiction in 10%. Silver et al. (...

Until the introduction of magnetic resonance imaging (MRI), all in vivo human studies, except for a single ca~ report (Menken et al. 1979), of the potential effects of electroconvulsive therapy (ECT) on brain structure had been retrospective comparisons of patients (with and without a history of prior ECT) who had had computerized tomographic scans. An association between prior ECT and lateral ...