CONTEXT Oral naltrexone can completely antagonize the effects produced by opioid agonists. However, poor compliance with naltrexone has been a major obstacle to the effective treatment of opioid dependence. OBJECTIVE To evaluate the safety and efficacy of a sustained-release depot formulation of naltrexone in treating opioid dependence. DESIGN AND SETTING Randomized, double-blind, placebo-c...

OBJECTIVE Leuprorelin acetate (TAP-144-SR) is commonly used worldwide in prostate cancer patients. This study was conducted to assess the non-inferiority of a 6-month depot formulation of TAP-144-SR (TAP-144-SR [6M]) 22.5 mg to a 3-month depot formulation of TAP-144-SR (TAP-144-SR [3M]) 11.25 mg in prostate cancer patients in Japan. METHODS This was a 48-week Phase III, open-label, parallel-g...

In this year-long, prospective observational study, sociodemographic, clinical, and functional characteristics were assessed in outpatients with schizophrenia from Australia, Mexico, Romania, and Taiwan who were switched from their primary oral antipsychotic to another oral or depot antipsychotic at study entry because of physician-perceived nonadherence risks. Patients (N = 406) rated their qu...

of prior cloud work: The PIs have built Depot, a cloud storage system that minimizes trust assumptions. Depot tolerates buggy or malicious behavior by any number of clients or servers, yet it provides safety and liveness guarantees to correct clients. Depot provides these guarantees using a two-layer architecture. First, Depot ensures that the updates observed by correct nodes are consistently ...

The paper describes the design, implementation, and evaluation of Depot, a cloud storage system that minimizes trust assumptions. Depot tolerates buggy or malicious behavior by any number of clients or servers, yet it provides safety and liveness guarantees to correct clients. Depot provides these guarantees using a two-layer architecture. First, Depot ensures that the updates observed by corre...

Using pigmented rabbits, two fluorophotometric methods for measuring aqueous flow were compared. A corneal depot of dye was used to measure aqueous flow in one eye of each rabbit while the vitreous depot method of Johnson and Maurice was used to measure aqueous flow over the same period in the fellow eye. After intravenous administration of acetazolamide or mannitol, during the first hour after...

Leuprolide acetate is a potent Gonadotropin Releasing Hormone (GnRH) agonist. The general premise behind leuprolide is that it inhibits the synthesis of lutenizing hormone and follicle stimulating hormone via a negative feedback. By reducing the production of these hormones, the drug effectively reduces estrogen and androgen production. This compound has been formulated as a depot formulation (...

BACKGROUND The size and geometry of an insulin depot that is formed during subcutaneous administration by an insulin pump is evaluated. A novel method is used to visualize accurately the depot formation for small volumes of insulin (of the order of 10-100 µl) at a given point in time. Conventional visualization methods such as magnetic resonance imaging are unable to provide such accurate measu...

Inspired by a real-life case in the Brussels Capital Region, Belgium, this paper provides Memetic Algorithm with Sequential Split procedure (MASS) for solving large variety of waste collection problems multiple depots, restricted vehicle fleet at each depot, (intermediate) processing facilities, capacity restrictions per facility and partial pick-ups. MASS first generates satisfactory initial s...

Outbound logistics is a crucial field of management. This study considers planning distribution for the poultry industry in Thailand. The goal to minimize transportation cost multi-depot vehicle-routing problem (MDVRP). A novel enhanced differential evolution algorithm (RI-DE) developed based on new re-initialization mutation formula and local search function. mixed-integer programming formulat...