OBJECTIVES Progestogens have been poorly studied concerning their roles in endothelial physiology. Prostanoids are vasoactive compounds, such as thromboxane A2, a potent vasoconstrictor, and prostacyclin, a vasodilator. We examined the effects of two progestogens used clinically, progesterone and medroxyprogesterone acetate, on thromboxane A2 production by cultured human umbilical vein endothel...

Norethindrone (17beta-hydroxy-19-nor-17alpha-pregn-4-en-20-yn-3-one) and norethindrone acetate (17beta-acetoxy-19-nor-17alpha-pregn-4-en-20-yn-3-one) interfered to a varying degree, by competitive inhibition, with the binding of progesterone and oestradiol to respective cytoplasmic receptors in the human uterus. Progesterone binding to 4S macromolecule was saturable and co-specific for progesti...

Progestins are widely used as oral contraceptives and hormone replacement therapy. Recently it has been demonstrated that many progestins are inhibitors of P-glycoprotein, possibly explaining gender differences in drug actions. In vitro evidence suggested that at least norgestimate might also inhibit other transporters like the multidrug resistance-associated protein 2 (MRP2). We therefore inve...

1. What exactly are injectable contraceptives, specifically DMPA and NET-EN? DMPA, or depot medroxyprogesterone acetate, and NET-EN, short for norethisterone enanthate, are contraceptives that contain a kind of hormone called progestin. Both are given by injection. DMPA (widely known by its marketed name Depo-Provera) is administered every three months, while NET-EN (or Noristerat) is given eve...

T.opically applied corticoids were shown to produce in man an increase in intraocular pressure, a reduction in outflow facility,' 2> G and dilatation of the pupil. In addition, important differences in this respect were depicted between the normal and glaucomatous eye.' These findings suggested an extensive search for a suitable laboratory animal in which these effects may be reproduced and the...

BACKGROUND Endometriosis is a common gynecological problem associated with chronic pelvic pain. OBJECTIVE To evaluate the effectiveness of current hormonal treatments of endometriosis associated pain. MATERIALS AND METHODS Randomized Controlled studies identified from databases of Medline and Cochrane Systemic Review groups were pooled. 7 RCTs were recruited for evaluation in this review. D...

the objective of the present study was to compare the impact of ovsynch and progesterone-based ovulation synchronization protocol on ovarian response and conception in buffalo (n=19) exhibiting subestrus during low-breeding season (maximum ambient temperatures and relative humidity ranging from 36-45°c and 30-80%, respectively). group i buffalo (n=10) were administered ovsynch protocol (d 0 and...