Human a1-acid glycoprotein (AAG) is a mixture of at least two genetic variants: the A variant and the F1 and/or S variant or variants, which are encoded by two different genes. In a continuation of previous studies indicating specific drug transport roles for each AAG variant according to its separate genetic origin, this work was designed to (1) determine the affinities of the two main gene pr...

Anomalous and supernumerary teeth, when present in the oral cavity may affect the facial harmony and esthetics. Managing patients with anomalous and supernumerary teeth poses a challenge for dentists especially, when smile esthetics is affected. We report management of a case of mesiodens associated with dens invaginatus, a rare presentation wherein the patient required immediate esthetic resto...

Co-occurrence of a talon cusp and double dens invaginatus is an extremely rare developmental dental anomaly. This case report represents a talon cusp with two dens invaginatus on a maxillary right lateral incisor. Early identification is needed for prevention of potential problems on the affected or opposing tooth.

Dens invaginatus is a rare developmental anomaly. It is unusual to find this anomaly in primary dentition. Diagnosis of this dens invaginatus is important due to possible pulpal involvement. Not only that, simultaneous presence of other dental anomaly may require long-term treatment planning. Dens invaginatus can be detected clinically in the tooth presenting unusual crown morphology or radiogr...

An accurate understanding of the morphology of the root canal system is a prerequisite for successful root canal treatment. Invaginated teeth have a complex root canal configuration that cannot be instrumented effectively. Correct diagnosis and treatment planning are fundamental to treatment of dens invaginatus. Periapical surgery is indicated in cases where a nonsurgical approach fails. A case...

Simultaneous occurrence of gemination and dens invaginatus in the same tooth is reported. Combined surgical and non surgical endodontic therapy was completed, with satisfactory results.

1DDS, MSc, PhD Graduate student in Pediatric Dentistry, Dental School – UNESPSão Paulo State University. 2DDS, Associate Professor of Endodontics, Dental School – UNESPSão Paulo State University and post graduation course in EndodonticsUNIMAR-Marília, SP. 3DDS, Associate Professor of Endodontics, Dental School – UNESPSão Paulo State University. 4DDS, Endodontist in private practice, Brasília, B...