BACKGROUND AND AIMS Doxorubicin is a potent anticancer drug and a major limiting factor that hinders therapeutic use as its high levels of systemic circulation often associated with various off-target effects, particularly cardiotoxicity. The present study focuses on evaluation of the efficacy of doxorubicin when it is loaded into the protein nanoparticles and delivered intravenously in rats be...

Following the Russian invasion of Ukraine this February, a global community volunteers has endeavored to help preserve Ukraine’s online cultural heritage. While comprises over 1300 volunteers, many them work as librarians or in preservation, including two leaders group, Quinn Dombrowski and Anna Kijas. Kijas, along with Sebastian Majstorovic, have been instrumental coordinating experts across t...

dena biosphere reserve located in iran and is a 550 biosphere reserve in the worlds. this research was investigated in the two protected and non-protected areas, in a dena biosphere reserve, kohkeloye va boyrahmad province, and central zagros forest, southwest of iran. inventory methods designed by systemetic-randomaiz method by use the rectangular plots that were 15×30 meters in the 100×100 m ...

Caloric restriction has been associated with a delay in the development of both spontaneous and induced neoplasia. In contrast, cycles of fasting/refeeding were shown by us and others to enhance the incidence of early lesions during chemical carcinogenesis in rat liver. The present, long-term study was undertaken to establish whether such a diffential effect would also extend to the later phase...

considering recent developments in earthquake engineering, researchers has detected different effects of earthquakes far and near from the fault. investigations that have been done in this area show that near fault earthquakes have shorter time period comparing far fault earthquakes and in the velocity of near fault earthquakes, there are one or more impacting pulses with a big domain and perio...

this paper presents a new observer design methodology for a time varying actuator fault estimation. a new linear matrix inequality (lmi) design algorithm is developed to tackle the limitations (e.g. equality constraint and robustness problems) of the well known so called fast adaptive fault estimation observer (fafe). the fafe is capable of estimating a wide range of time-varying actuator fault...

the idea of this paper is designing an automatic fault detection system based on fuzzy logic, therefore two signals of pmsm in fault condition are analyzed for inter turn fault detection: current and torque. in this fault type there is some distortion in these signals, but it is not good enough to detecting with fuzzy logic solely, so with combination of wavelet transform and fcm a new method f...

Steering assist system controls the force transfer behavior of the steering system and improves the steering probability of the vehicle. Moreover, it is an interface between the diver and vehicle. Fault detection in electrical assisted steering systems is a challenging problem due to frequently use of these systems. This paper addresses the fault detection and reconstruction in automotive elect...

the present study aimed at investigating the effect of different levels of nitrogen on yield and yield components of bread and durum wheat. to this end the experiment was conducted in 2010-2011 in south west of iran as split plots based on randomized complete block design with three replications. main plot included four levels of nitrogen 60, 120, 180, 240 kg.ha-1 and the sub plot included four...