Lynch syndrome is one of the most common hereditary cancer syndromes. Although Lynch syndrome is associated with increased risk for developing colorectal, endometrial, and other cancers specialized screening, risk-reducing surgery, and chemoprevention offer promise for reducing morbidity and mortality. Frequent colonoscopic surveillance has proven effective for early detection and prevention of...

Lynch syndrome describes a familial cancer syndrome comprising germline mutations in one of four DNA mismatch repair genes, MLH1, MSH2, MSH6, and PMS2 and is characterized by colorectal, endometrial, and other epithelial malignancies. Thyroid cancer is not usually considered to be part of the constellation of Lynch syndrome cancers nor have Lynch syndrome tumor gene mutations been reported in t...

BACKGROUND Universal tumor screening for Lynch syndrome, the most common form of hereditary colorectal cancer (CRC), has been recommended among all patients newly diagnosed with CRC. However, there is limited literature regarding patient perspectives of tumor screening for Lynch syndrome among patients with CRC who are not selected for screening based on family history criteria. METHODS A tot...

Crowley, Terry (edited by John Lynch), The Avava language of Central Malakula (Vanuatu). Canberra: Department of Linguistics, Research School of Pacific and Asian Studies, Australian National University, 2006, xvi + 213 pp. [Pacific Linguistics 574.] ISBN 0858835649. Price: AUD 54.50 (paperback). Crowley, Terry (edited by John Lynch), Tape: a declining language of Malakula (Vanuatu). Canberra: ...

PURPOSE A woman with early-onset endometrial cancer (EC) may represent the "sentinel" cancer event in a Lynch syndrome kindred. The aim of this study was to determine the incidence of Lynch syndrome in a series of young-onset EC, and to identify molecular, clinical, and pathologic features that may alert clinicians to the presence of this disorder. EXPERIMENTAL DESIGN Patients with EC, ages <...

The cardinal features of colorectal cancer in patients with the MUTYH-associated polyposis syndrome, featured in this editorial, are of very recent discovery and remain under review as new clinical phenotypes for these patients are still being identified. Importantly, its phenotype results from homozygosity of the MUTYH gene and, therefore, is inherited in an autosomal recessive pattern. In a m...

The hallmark of Lynch Syndrome is a germ line mutation in one of the enzymes involved in DNA mismatch repair (MMR). The diagnosis of Lynch Syndrome is of particular relevance in colorectal and endometrial cancer cases, and several testing modalities including IHC, PCR, methylation studies, and genetic sequence analysis are used for its evaluation. As many sporadic cancers exhibit MMR deficiency...

Introduction Myocardial involvement in polymyositis has been increasingly recognized since it was first reported by Oppenheim (1899). Cardiac manifestations include congestive cardiac failure (Lynch, 1971; Bohan et al., 1977; Denbow et al., 1979), pericarditis (Lynch, 1971), atrioventricular and bundle branch block (Lynch, 1971, Schaumburg, Nielsen and Yurchak, 1971; Henderson et al., 1980) and...