YB-1 is a broad-specificity RNA-binding protein that is involved in regulation of mRNA transcription, splicing, translation, and stability. In both germinal and somatic cells, YB-1 and related proteins are major components of translationally inactive messenger ribonucleoprotein particles (mRNPs) and are mainly responsible for storage of mRNAs in a silent state. However, mechanisms regulating th...

BACKGROUND The CC chemokine CCL5/Regulated on Activation, Normal T Cell Expressed and Secreted (RANTES) is upregulated in mononuclear cells or deposited by activated platelets during inflammation and has been implicated in atherosclerosis and neointimal hyperplasia. We investigated the influence of the transcriptional regulator Y-box binding protein (YB)-1 on CCL5 expression and wire-induced ne...

The human Y-box binding protein, YB-1, is a multifunctional protein that regulates gene expression. Nuclear expression of YB-1 has been associated with chemoresistance and poor prognosis of tumour patients. Representative samples from autopsied material of primary tumours from 77 patients with NSCLC were investigated by immunohistochemistry for subcellular distribution of YB-1 and p53, in order...

Prostaglandin E2 (PGE2) has been implicated in hepatocellular carcinoma cell invasion. Recently, it was reported that Y box-binding protein 1 (YB-1) is closely correlated with malignancy. This study was designed to examine the mechanisms by which PGE2 increases YB-1 expression and promotes HCC cell invasion. PGE2 greatly enhanced HCC cell invasion through upregulation of the YB-1 protein, and t...

Three cold shock domain (CSD) family members (YB-1, MSY2, and MSY4) exist in vertebrate species ranging from frogs to humans. YB-1 is expressed throughout embryogenesis and is ubiquitously expressed in adult animals; it protects cells from senescence during periods of proliferative stress. YB-1-deficient embryos die unexpectedly late in embryogenesis (embryonic day 18.5 [E18.5] to postnatal day...

A series of NaLuF4-based hexagonal phase upconversion nanocrystals (UCNs) were synthesized by a facile solvothermal method and the properties of the UCNs were investigated. The results show that the as-prepared nanocrystals exhibit pure hexagonal lattice structures, uniform morphologies, high monodispersities and excellent upconversion luminescence. The upconversion luminescence (UCL) intensiti...

Er(3+)/Yb(3+)/Pr(3+): SrGdGa3O7 crystal was firstly grown by Czochralski method. Detailed spectroscopic analyses of Er(3+)/Yb(3+)/Pr(3+): SrGdGa3O7 were carried out. Besides better absorption characteristic, the spectra of Er(3+)/Yb(3+)/Pr(3+): SrGdGa3O7 show weaker up-conversion and near-infrared emissions as well as superior mid-infrared emission in comparison to Er(3+): SrGdGa3O7 and Er(3+)/...

Proof of Theorem 4. For wa ∈ [c + ck, rck w−c ], we have the boundary equilibrium. From its definition, yb(ξ) is decreasing in wa (that is, dyb(ξ) dwa < 0) and yb(ξ) = μ + ξ + G−1( r−c−ck r ) when wa = c + ck. The total supply chain profit at the boundary equilibrium is Πtot(yb(ξ), yb(ξ), ξ) = rEmin(μ + ξ + , yb(ξ)) − (c + ck)y(ξ) from Equations (16) and (17). This function is concave and incre...

The Y-box-binding protein 1 (YB-1), a member of the cold-shock domain RNA-and DNA-binding protein family, has pleiotropic functions such as regulation of the cell cycle. The aim of this study was to evaluate if YB-1 is a proliferative marker in breast cancer and elucidate potential downstream targets involved in YB-1-mediated cell cycle regulation using RNA interference technology. YB-1 protein...

BACKGROUND Y-Box-binding protein-1 (YB-1) acts as a transcription factor for multiple genes and is linked to DNA replication and repair, cell proliferation and resistance to cytostatic drugs. PATIENTS AND METHODS The prognostic value of YB-1 expression in primarily untreated malignant non-Hodgkin's lymphomas (NHLs) was examined using immunohistochemistry. RESULTS Expression of YB-1 was dete...