The in vitro susceptibilities of 151 unique clinical isolates of Mycoplasma pneumoniae, Mycoplasma hominis, Mycoplasma fermentans, Mycoplasma genitalium, and Ureaplasma species to DC-159a, an investigational fluoroquinolone, in comparison with those to other agents were determined. Macrolides were the most active agents against M. pneumoniae and M. genitalium, whereas clindamycin was most activ...

Down-regulation of the immune response in aging individuals puts this population at a potential risk against infectious agents. In-depth studies conducted in humans and mouse models have demonstrated that with increasing age, the T cell immune response against pathogens is compromised and response to vaccinations is subdued. In the present study, using a mouse model, we demonstrate that older a...

In early life, a high susceptibility to infectious diseases as well as a poor capacity to respond to vaccines are generally observed as compared with observations in adults. The mechanisms underlying immune immaturity have not been fully elucidated and could be due to the immaturity of the T/B cell responses and/or to a defect in the nature and quality of Ag presentation by the APC. This prompt...

We investigated whether a developmental immaturity of the dendritic cells (DCs) compartment could contribute to the high susceptibility to infections observed in newborns. DCs are among the first cells to colonize the spleen, but the ontogeny of DC subsets follows distinct steps. At birth, plasmacytoid DCs and CD4-CD8alpha- DCs are found in the spleen, whereas CD8alpha+ and CD4+ DCs are not pre...

In this paper a complete robust control synthesis is performed for a hybrid power generation structure composed by a Fuel Cell and a Supercapacitor. The control strategies are applied to the DC-DC boost power converters associated to each power source. Multivariable PI control withH∞ performance,H∞ full and reduced order controllers are designed and compared. The multivariable PI controller is ...

This paper presents the basic characteristics of the digitally controlled boost type dc-dc converter. The static and dynamic characteristics of the dc-dc converter with the digital PID control are discussed. Especially, it is examined that the A-D conversion timing and anti-aliasing filter’s cut-off frequency affect the dynamic and static characteristics. As a result, when the anti-aliasing fil...