نتایج جستجو برای: dba
تعداد نتایج: 3851 فیلتر نتایج به سال:
Pancreatic carcinoma ranks among the most lethal of human cancers. Besides late detection, other factors contribute to its lethality, including a high degree of chemoresistance, invasion, and distant metastases. Currently, the mainstay of therapy involves resection of local disease in a minority of patients (Whipple procedure) and systemic gemcitabine. While systemic chemotherapy has some benef...
BACKGROUND Diamond Blackfan anemia (DBA), characterized by impaired red cell production, is a rare condition that is usually symptomatic in early infancy. The purpose of this study was to assess nationwide experiences of DBA encountered over a period of 20 years. METHODS The medical records of 56 patients diagnosed with DBA were retrospectively reviewed from November 1984 to July 2010. Fiftee...
Dynamic binary analysis (DBA) tools such as profilers and checkers help programmers create better software. Dynamic binary instrumentation (DBI) frameworks make it easy to build new DBA tools. This dissertation advances the theory and practice of dynamic binary analysis and instrumentation, with an emphasis on the importance of the use and support of metadata. The dissertation has three main pa...
Dibromoacetic acid (DBA) and bromochloroacetic acid (BCA) are prevalent disinfection by-products of drinking water that produce defects in spermatogenesis and fertility in adult rats. Previously we demonstrated that BCA compromises the fertility of cauda epididymal rat sperm and SP22, a sperm membrane protein that is highly correlated with the fertility of these sperm. Herein, we administered D...
The interactions of human genotype AO erythrocytes (red blood cells) (RBCs) with N-acetylgalactosamine-reactive lectins isolated from Helix pomatia (HPA) and from Dolichos biflorus (DBA) were studied. Binding curves obtained with the use of tritium-labeled lectins showed that the maximal numbers of lectin molecules capable of binding to human genotype AO RBCs were 3.8 X 10(5) and 2.7 X 10(5) mo...
OBJECTIVE DBA/2 apoE(-/-) mice have ≈10-fold larger lesions than AKR apoE(-/-) mice. The objective of this study was to determine whether macrophages from these 2 strains had altered cholesterol metabolism that might play a role in their divergent atherosclerosis susceptibility. APPROACH AND RESULTS AKR and DBA/2 macrophages incubated with acetylated low-density lipoprotein resulted in higher...
BACKGROUND Prior research has reported disparities in environmental exposures in the United States, but, to our knowledge, no nationwide studies have assessed inequality in noise pollution. OBJECTIVES We aimed to a) assess racial/ethnic and socioeconomic inequalities in noise pollution in the contiguous United States; and b) consider the modifying role of metropolitan level racial residential...
bstract—Characterizing the responses of different mouse trains to experimentally-induced seizures can provide clues to he genes that are responsible for seizure susceptibility, and actors that contribute to epilepsy. This approach is optimal hen sequenced mouse strains are available. Therefore, we ompared two sequenced strains, DBA/2J (DBA) and A/J. These trains were compared using the chemocon...
OBJECTIVES This study examined the relative efficacies of a derivative of betulinic acid (dBA) and its poly (lactide- co-glycolide) (PLGA) nano-encapsulated form in A549 lung cancer cells in vivo and in co-mutagen [sodium arsenite (SA) + benzo]undefined[a]pyrene (BaP)]-induced lung cancer in mice in vivo. METHODS dBA was loaded with PLGA nanoparticles by using the standard solvent displacemen...
Characterizing the responses of different mouse strains to experimentally-induced seizures can provide clues to the genes that are responsible for seizure susceptibility, and factors that contribute to epilepsy. This approach is optimal when sequenced mouse strains are available. Therefore, we compared two sequenced strains, DBA/2J (DBA) and A/J. These strains were compared using the chemoconvu...
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