Conservation of gene and protein sequence, and, therefore, conservation of the resulting molecular interactions that mediate biological processes, is foundational to our understanding of biology. This conservation allows discovery in one organism, such as worms or mice, to inform our understanding of the biology in another organism, such as humans. However, there is emerging recognition that ma...

The expression of P-glycoprotein (Pgp) is often increased in acute myeloid leukemia (AML). However, little is known of the regulation of Pgp expression by cytotoxics in AML. We examined whether Pgp expression and function in leukemic blasts was altered after a short exposure to cytotoxics. Blasts were isolated from 19 patients with AML (15 patients) or chronic myeloid leukemia in blastic transf...

Abstract With current semiconductor technology reaching its physical limits, special-purpose hardware has emerged as an option to tackle specific computing-intensive challenges. Optimization in the form of solving quadratic unconstrained binary optimization problems, or equivalently Ising spin glasses, been focus several new dedicated platforms. These platforms come many different flavors, from...

A major deficiency in state-of-the-art automatic speech recognition (ASR) systems is the lack of robustness in additive and convolutional noise. The model of auditory perception (PEMO), developed by Dau et al. (1996a) for psychoacoustical purposes, partly overcomes these difficulties when used as a front end for automatic speech recognition. To further improve the performance of this auditory-b...

In the field theoretical Glauber-Gribov framework in the eikonal approximation, we show that, in hadron-nucleus collisions in the high-energy limit and under especific conditions, the rescattering contributions to the J/ψ production cross-section vanish, leading to an A1 dependence on the atomic number A – except for nuclear effects in the nucleus structure function, the so-called shadowing. We...

We study the effect of spatially homogeneous and inhomogeneous shadowing on J/psi production in deuterium-nucleus collisions. We discuss how the shadowing and its spatial dependence can be measured by comparing central and peripheral dA collisions. These event classes may be selected by using gray protons from heavy ion breakup and events where the proton or neutron in the deuterium does not in...

Objective: 5-HT receptors are present in human atrial cells and their stimulation has been implicated in the genesis of atrial 4 arrhythmias including atrial fibrillation. An I -like current has been recorded in human atrial myocytes, where it is modulated by f ß-adrenergic stimulation. In the present study, we investigated the effect of serotonin (5-hydroxytryptamine, 5-HT) on I electrof physi...

Dalam pelatihan Batik ecoprint tahun ini, sasaran utama adalah pendidik SDM 8 DAU di Kabupaten Malang. Mereka merupakan hebat dalam melestarikan budaya setempat khususnya Malang serta sebagai modal berwirausaha. Hal ini dimaksudkan untuk mengajarkan kepada anak didiknya mempersiapkan mereka lebih kreatif dan diharapkan mampu menciptakan kemandirian usaha dengan mendirikan unit kecil. sendiri pe...