Pemphigus foliaceus (PF) is rarely described in the pediatric population with less than 40 cases reported in the literature. We report the case of an 11-year-old girl who was diagnosed with PF after 6 months of starting with symptoms and who responded well to therapy with oral dapsone. Although therapeutic guidelines for PF in children are lacking, oral corticosteroids in combination with dapso...

The chemotherapy of leprosy needs both to be as effective and also, certainly under field conditions, as safe, cheap, short, acceptable and easy to apply as possible. Now, 4 years after the introduction of the WHO Study Group regimens ! is a very appropriate moment to review progress in multidrug therapy (MDT) . The possibility of MDT of limited duration was pioneered by Professor Freerksen and...

The introduction of effective antimicrobial treatment for leprosy, first with the sulphones by Faget in 1943, was the major scientific development of the twentieth century to actually alter disease course and provide patients reason to hope. Initially promin and solapsone, injectable sulphones, were utilised, but these injectables were soon abandoned for oral dapsone which had the additional ad...

A new spectrophotometric method for the determination of each dapsone and metoclopramide HCl alone in two different tablet preparations is described. The reactions were completed at room temperature within 9 and 20 minutes, respectively. Maximum absorbances for the reaction products were observed at 548 nm (dapsone) and 553 nm (metoclopramide HCl). Beer’s law was obeyed over the concentration r...

The outcome of attempts to continue treatment indefinitely with either gold, penicillamine, sulphasalazine, or dapsone was studied in 240 patients with rheumatoid arthritis (RA). The usual reason for discontinuing treatment was the occurrence of an adverse effect. This led to 53% of patients stopping gold, 33% sulphasalazine, 32% penicillamine, and 17% dapsone. The next most frequent reason was...

Granuloma annulare is a dermatosis of unknown cause that is generally self-limiting and has several clinical forms of presentation. It may be associated with pruritus or present asymptomatically. The disseminated variant of the disease accounts for 15 % of all cases. Most authors consider that the duration of this form is longer and that treatment response is worse than for localized forms. A r...

The objective of the present study was to define short-course treatment regimens for PB leprosy and to compare them with the 'classical' dapsone treatment and the WHO-PB regimen. Five treatment regimens were studied and evaluated by the histologic evolution. The regimens were: (1) dapsone 100 mg daily, non-supervised for 3 years; (2) RMP 900 mg supervised, once weekly, 8 doses; (3) idem 12 dose...

Twenty years ago, dapsone resistance had become so widespread a phenomenon among both treated and untreated leprosy patients, that the achievements of leprosy control obtained during the preceding 30 years by large scale dapsone monotherapy were in serious jeopardy. To avert the further spread of dapsone resistance, immediate implementation of multidrug therapy (MDT) was recommended by the WHO ...

Background & Aims: Leishmaniasis exists in more than half of Iran provinces and more than 20,000 cases are reported annually. In the recent years, several therapeutic approaches such as topical and physical treatments have been investigated. In the present study, the efficacy of co-administration of topical Niosomal Dapsone gel and Glucantime intralesional injection has been evaluated. Method: ...