Right ventricular (RV) failure is a major cause of death in patients with pulmonary arterial hypertension, and the mechanism RV remains unclear. While malfunction RyR2 (ryanodine receptor type 2) on sarcoplasmic reticulum (SR) aberrant Ca 2+ cycling cardiomyocytes have been recognized some cardiovascular diseases, their roles secondary to hypertension require further investigation. In monocrota...

BACKGROUND We analyzed cases of malignant hyperthermia (MH) reported to the North American MH Registry for clinical characteristics, treatment, and complications. METHODS Our inclusion criteria were as follows: AMRA (adverse metabolic/musculoskeletal reaction to anesthesia) reports between January 1, 1987 and December 31, 2006; "very likely" or "almost certain" MH as ranked by the clinical gr...

Dantrolene is the drug of choice for the treatment of malignant hyperthermia (MH) and is also useful for treatment of spasticity or muscle spasms associated with several clinical conditions. The current study examines the mechanisms of dantrolene's action on skeletal muscle and shows that one of dantrolene's mechanisms of action is to block excitation-coupled calcium entry (ECCE) in both adult ...

We report the case of a 31-year-old man with Graves' disease who manifested malignant hyperthermia during subtotal thyroidectomy. His past medical history and family history were unremarkable. Before surgery, his condition was well controlled with propylthiouracil, ,l-adrenergic blocker and iodine. During the operation, anesthesia was induced by intravenous injection of vecuronium and thiopenta...

BACKGROUND 3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") can mediate acute toxic effects such as muscle rigidity, metabolic acidosis, and hyperthermia. Because of close clinical similarities, an association between MDMA intoxication and malignant hyperthermia (MH) was suggested. The aim of this study was to investigate whether MDMA is a trigger of MH in susceptible swine. METHODS MH-non...

MH produces rapid increase in body temperature (by as much as 1oC in five minutes) and extreme acidosis. These are a result of acute loss of control of intracellular calcium levels and compensatory uncontrolled increases in skeletal muscle metabolism, which may progress to severe rhabdomyolysis. Critical worldwide attention to MH began in 1960 with the reports of Denborough and Lovell. They des...

Abstract Background Patients with severe COVID-19 have disorders of the respiratory, cardiovascular, coagulation, skeletal muscle, and central nervous systems. These systemic failures may be associated cytokine release syndrome, characterized by hyperpyrexia, thrombocytopenia, hyperferritinemia, elevation other inflammatory markers. Rhabdomyolysis high fever is a complication that rarely found ...