We wanted to evaluate the improvement in efficacy when increasing the daily dose of inhaled steroids and to compare the efficacy, safety, and tolerance of 1.6 mg beclomethasone dipropionate (BDP) with that of 2.0 mg fluticasone propionate (FP). The study was a randomized, double-blind, 3 month, multicentre study. One hundred and thirty four asthmatics currently using inhaled steroids (0.4-1.6 m...

The effect of initial airway calibre on the response to bronchial provocation is unclear. Theoretically, geometric relationships within the airways might influence the measurement of responsiveness, particularly since a given change in calibre will produce a disproportionately greater reduction in flow in airways which are already narrowed. We have examined the relationship between serial measu...

abstract introduction: yoga as an exercise to improve the physical, psychological, social health condition, and promote the feeling of health in healthy people in the medical education community is considered. the aim of this research was to find the effect of 8 weeks yoga training on respiratory function and heart rate of non-athlete females. methods: 30 students of khorasgan azad university w...

The within subject variability of forced vital capacity (FVC), forced expiratory volumes in one second (FEV1) and half a second (FEV0.5), peak expiratory flow (PEF), and flow rates at 25-75%, 75-85%, 25%, 50%, and 75% of expired FVC were assessed among 7 year old children from the general population. Within occasion variability in 232 children was lowest for FVC (coefficient of variation (CV) 5...

Whilst the trials quoted in the Cochrane reviews [5–7] provide various degrees of quality of evidence, the key information that is missing from these studies is an understanding of the physiological principles by which these different techniques work. Physiologically, the techniques need to do the following. 1) Increase absolute peak expiratory flow (PEF) to move secretions towards the orophary...

Rhinovirus (RV) colds are associated with asthma exacerbations and experimental infections are commonly used to investigate the mechanisms involved. However, a temporal association between experimental RV infections and falls in peak expiratory flow (PEF) have not been demonstrated. PEF was measured in 22 volunteers (11 normal, five atopic, six atopic asthmatic) who developed RV serotype 16 col...

BACKGROUND Exercise-induced bronchoconstriction (EIB), which describes acute airway narrowing that occurs as a result of exercise, is associated with eosinophilic airway inflammation, bronchial hyperresponsiveness. The forced expiratory volume in one second (FEV1) is the most commonly used spirometric test in the diagnosis of EIB in exercise challenge in asthma. Other parameters such as forced ...

A study was undertaken to examine the circadian rhythm of peak flow rate in asthmatic and normal children in the community by means of cosinor analysis. An initial study of 12 matched pairs of asthmatic and normal children was used to determine the mean amplitude of peak expiratory flow (PEF) variability in the two groups (7.8% and 4.4%) and the number of subjects required to show a significant...

Laboratory animal workers are at risk of developing allergic symptoms, of which asthmatic symptoms are the most severe. The aim was to study the relationship between allergic symptoms due to working with rats and variability and changes in peak expiratory flow (PEF). Several indices were used on the basis of the amplitude of the PEF or the differences in PEF between days with and without exposu...

OBJECTIVE To evaluate efficacy, safety, health outcomes, and cost-effectiveness of fluticasone propionate (FP) versus montelukast (MON) in 342 children (6 to 12 years of age) with persistent asthma. STUDY DESIGN Randomized, double-blind, 12-week study of treatment with FP inhalation powder 50 mug twice daily or MON chewable 5 mg once daily for 12 weeks. RESULTS Compared with MON, FP signifi...