Huntington's disease (HD) is caused by polyglutamine expansion (exp) in huntingtin. Here, we used a yeast artificial chromosome (YAC) transgenic mouse model of HD to investigate the connection between disturbed calcium (Ca2+) signaling and apoptosis of HD medium spiny neurons (MSN). Repetitive application of glutamate elevates cytosolic Ca2+ levels in MSN from the YAC128 mouse but not in MSN fr...

Multifunctional mesoporous silica nanoparticles (MSN) with well-integrated multimodality imaging properties have generated increasing research interest in the past decade. However, limited progress has been made in developing MSN-based multimodality imaging agents to image tumors. We describe the successful conjugation of, copper-64 ((64)Cu, t1/2 = 12.7 h), 800CW (a near-infrared fluorescence [...

Groenhoff, MSN, MBA, RN, CNN (South Florida Flamingo Chapter), Sue McManus, MSN, CFNP, CNN (Acadiana Chapter); and Janie Martinez, BSN, RN, CCRN, CNN (Alamo Chapter); ANNA members Emily Hodgin, BSN, RN, CNN, CPHQ (Cardinal Chapter); Carmen Mejias, BSN, RN, CNN (Heart of Texas Chapter); Betsy King, MSN, RN, CNN; (Northeast TriState Chapter); Darene Hall, MSN, RN, CNN (Chumash Chapter); and Glady...

and Roman Skála , Department of Geological Sciences, Faculty of Sciences, Masaryk university, Kotlářská 2, CZ-61137 Brno, Czech Republic, e-mail: [email protected], Brno University of Technology, Faculty of chemistry, Purkyňova 118, CZ-61200 Brno, Institute of Computer Science, Academy of Sciences of the Czech Republic, Pod Vodárenskou věží 2, CZ-18207 Prague 8, Czech Republic, Institute ...

We studied the macrophage (Mo) activation pathways through Mo interaction with immunogenic Trypanosoma cruzi antigens as cruzipain (Cz) and R13. J774 cells, peritoneal and spleen Mo from normal mice, were used. Although Mo classic activation was observed in the presence of lipopolysaccharide, evaluated through nitric oxide (NO) and interleukin (IL)-12 production, Cz and R13 did not activate Mo ...

We developed a potential immunostimulatory double-stranded DNA (dsDNA) delivery system by the binding of dsDNA to amino-modified mesoporous silica nanoparticles (MSNs) to form MSN-NH2/dsDNA complexes. Serum stability, in vitro cytotoxicity, cell uptake, and type I interferon-α (IFN-α) induction of MSN-NH2/dsDNA complexes were evaluated. The results showed that MSN-NH2 nanoparticles had no cytot...

Abstract: Service Convergence is a prospective goal to reach considerable economic benefits in a Multi-Service Network (MSN) environment. Elements such as Multi-Service Provisioning Platforms and Multi-Technology Network Management systems together with suitable MSN modeling are the key underlying components supporting that goal. The paper relates to the framework of MSN modeling and specifical...

The encapsulation of [Eu(dbm)3phen] into functionalized mesoporous silica nanoparticles (MSN) has been carried out to study the effect of chemical environments on the photoluminescence properties of the rare-earth complex. Surface functionalization was achieved by the reaction of the silanol groups on the surface of mesoporous silica with different organosilylating agents such as (3-aminopropyl...

Abstract – In this paper we examine the problem of resilience in a Clockwork Routing scheme employed in a Manhattan Street Network (MSN) network architecture. The MSN has been proposed as a promising candidate for high-speed optical packet-switched applications. In this paper, we study the impact of single physical link or node failures on the self-routing topology and the effects on the routin...

Bu çalışmada çok gözenekli (MSN) ve tek (HSS) silika nanopartiküllerin yüzeyinde, viniltriazol (VTri) monomerinin polimerizasyon reaksiyonu ile amin grupları oluşturulmuştur. Hazırlanan nanokompozit yapıların karakterizasyonu antifungal özelliği incelenmiştir. Nanokompozitlerin karakterizasyonunda MSN HSS' nın etkileşimini, yüzeydeki azol gruplarının varlığını belirlemek için FTIR XRD analizi, ...