It is likely that many different in vitro cytotoxicity methods could be used to help select the in vivo starting dose for an acute lethality assay. Two decades of experience indicate that in vitro basal cytotoxicity data determined in various primary cells, as well as in various permanent nondifferentiated finite or transformed cell lines, generally show comparable cytotoxic concentrations of t...

As bioabsorbable materials, magnesium alloys are expected to be totally degraded in the body and their biocorrosion products not deleterious to the surrounding tissues. It's critical that the alloying elements are carefully selected in consideration of their cytotoxicity and hemocompatibility. In the present study, nine alloying elements Al, Ag, In, Mn, Si, Sn, Y, Zn and Zr were added into magn...

The National Cancer Institute (NCI) Human Tumor Cell Line Anti-Cancer Drug Screen has evaluated the cytotoxicity profiles of a large number of synthetic compounds, natural products, and plant extracts on 60 different cell lines. The data for each compound/extract can be assessed for similarity of cytotoxicity pattern, relative to a given test compound, using an algorithm called COMPARE. In appl...

Background: Apple cider vinegar potentially can be used as an alternative to irrigation solutions because of its antibacterial compounds that inhibit Enterococcus faecalis, a pioneer bacteria cause root canal treatment failure. One the ideal solution requirements is it isn’t toxic oral cavity tissues, so it’s necessary run cytotoxicity test on apple solution. Cytotoxicity initial part evaluatio...