Background: Radiotherapy and adjuvant androgen deprivation therapy have historically been the first treatment choices for prostate cancer but treatment resistance often limits the capacity to effectively manage the disease. Therefore, alternative therapeutic approaches are needed. Here, the efficacies of radiotherapy and targeting the pro-survival cell signaling components epidermal growth fact...

Two patients with stage IIIB Hodgkin's disease are reported, in whom treatment with cytotoxic and corticosteroid therapy was followed by avascular necrosis of the femoral head.

Treatment approaches for relapsed ovarian cancer have evolved over the past decade from a calendar-based decision tree to patient-oriented biologically driven algorithm. Nowadays, platinum-based chemotherapy should be offered all patients with reasonable chance of responding this therapy. The treatment-free interval platinum is only one many factors affecting patients' eligibility re-treatment....

cancer is a major cause of death worldwide and causes serious problems in human life. it is developed by uncontrolled growth of a cell or a group of cells. there are many difficulties in treatment of cancer and many researchers are involved in investigating for effective drugs to treat the disease. caryophyllaceae is a large family of about 86 genera and 2200 herbaceous or subshrub species. the...

the present study was intended to standardize the protocol for the synthesis of silver nanoparticles (agnps) using aqueous extract of dictyota bartayresiana j.v. lamouroux and evaluate cytotoxic potentials using brine shrimp bio-assay activity and trypan blue dye exclusion method. the reduction of pure ag+ ions was monitored by measuring the uv-vis spectrum of the solution at 200-900 nm and the...

background and objective: in addition to the use of chemicals in food, pharmaceutical, cosmetic and hygiene industries, use of herbal and natural compounds have also increased. it seems natural ingredients compared with the chemical components show less side effects, such as mutagenicity and carcinogenesis however, their use can also be associated with side effects and toxicity. some significan...

Hemophagocytic lymphohistocytosis (HLH) is a hyperinflammatory syndrome that occurs at all ages and is characterized by high levels of cytokines, secreted by activated T-lymphocytes and macrophages. All symptoms and laboratory changes can be explained by organ infiltration by these cells and hypercytokinemia. HLH occurs as an inherited form (genetic, primary HLH) with mutations primarily in the...

This paper discusses the role of peptides in cancer therapy with special emphasis on peptide drugs which are already approved and those in clinical trials. The potential of peptides in cancer treatment is evident from a variety of different strategies that are available to address the progression of tumor growth and propagation of the disease. Use of peptides that can directly target cancer cel...

Anticancer therapy for solid tumors suffers from inadequate methods for the localized administration of cytotoxic agents. Fas ligand (FasL) has been reported to be cytotoxic to a variety of cells, including certain tumor cell lines. We therefore postulated that myoblasts could serve as non-transformed gene therapy vehicles for the continuous localized delivery of cytotoxic anticancer agents suc...