The expression of intermediate filaments of the keratin- and the vimentin-type was studied in heterokaryons of human fibroblasts and amnion epithelial cells by immunofluorescence microscopy. Fibroblasts and their homokaryons showed a fibrillar, vimentin-specific fluorescence throughout the cytoplasm but were negative when stained for keratin. Amnion epithelial cells and their homokaryons, on t...

The cytokeratin network is an abundant cytoplasmic system whose function is largely unknown. Recently, we have found that the introduction of a cytokeratin network into eukaryotic cells results in a drug resistance phenotype. The current study was undertaken to determine the universal nature of this phenomenon by investigating the survival response of two different cell lines to six different D...

I N T R O D U C T I O N The treatment of epithelial tumors continues to be a major medical challenge due in part to both cellular and noncellular Received 4/19/95; revised 8/23/95; accepted 9/20/95. Supported in part by a research fellowship award from the ASTRO Education and Development Fund, Grants CA56666 and CA23074, and DOE Contract 307190. Financial support does not constitute an endorsem...

The effects of epidermal growth factor (EGF) on the cytokeratin filaments of cultured murine epithelial cells were studied by the indirect immunofluorescence technique with affinity-purified antibodies. Mouse epithelial cells (MMC-E), grown on glass cover slips, and viewed by immunofluorescence microscopy, showed keratin-specific fluorescence as typical bright perinuclear aggregates correspondi...

INTRODUCTION Cytokeratins are important part of cytoskeleton. Cytokeratin 19 (CK 19) belongs to type I cytokeratins. Lung cancer is currently most frequently diagnosed neoplasm in males in many developed countries and in Poland. The prognosis in lung cancer remains unfavourable. The aim of this study was to evaluate the prognostic value of cytokeratin 19 expression in non-small cell lung cancer...

Background: Low-grade oncocytic tumour (LOT) is an emerging entity describing a slow growing with morphologic features overlapping between chromophobe renal cell carcinoma (ChRCC) and oncocytoma, staining positive for cytokeratin-7 negative CD117 (c-kit). This has been recently recognised in the WHO classification of tumours 5th edition 2022. Presentation: In this case report, we present 77-yea...

BACKGROUND Cytoskeletal changes after longterm exposure to ethanol have been described in a number of cell types in adult rat and humans. These changes can play a key part in the impairment of nutrient assimilation and postnatal growth retardation after prenatal damage of the intestinal epithelium produced by ethanol intake. AIMS To determine, in the newborn rat, which cytoskeletal proteins a...