BACKGROUND Childhood acute lymphoblastic leukemia (ALL) is characterized by recurrent genetic aberrations. The identification of those abnormalities is clinically important because they are considered significant risk-stratifying markers. AIMS There are insufficient data of cytogenetic profiles in Saudi Arabian patients with childhood ALL leukemia. We have examined a cohort of 110 cases of AL...

Myelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic stem cell disorders with variable clinical outcome. The International Prognostic Scoring System (IPSS) categorizes untreated MDS patients into one of four risk groups (low, intermediate [Int]-1, Int-2 and high) based on the percentage of bone marrow blasts, presence of cytogenetic abnormalities and number of cytopenias. ...

Prognostic factors in acute myeloid leukemia (AML) may be subdivided into those related to patient characteristics and general health condition, and those related to characteristics of the tumor.[1] Among the AML-related factors, the karyotype of the leukemic cells is the strongest independent prognostic indicator for response to therapy and for survival, and allows one to stratify patients int...

PURPOSE The purpose of this study was to identify the financial management educational needs of nurses in order to development an educational program to strengthen their financial management competencies. METHODS Data were collected from two focus groups using the nominal group technique. The study consisted of three steps: a literature review, focus group discussion using the nominal group t...

Abstract Background Fetal growth restriction (FGR) is associated with increased risks for complications before, during, and after birth, in addition to risk of disease through adulthood. Although placental insufficiency, failure supply the fetus adequate nutrients, underlies most cases FGR, its causes are diverse not fully understood. One few diagnosable insufficiency ongoing pregnancies presen...

introduction: fragile x syndrome (fxs) is one of the most prevalent genetic causes of developmental disability, representing the most frequent form of inherited severe cognitive deficit. the present study was undertaken to investigate fxs and its prevalence in moderate mentally retarded people in patients. materials and methods: nineteen people with moderate mental retardation (mr) who were cli...

Acute myeloid leukaemia (AML) is a heterogeneous disease covering a range of morphological lineages and differentiation stages, but also has number of recurrent chromosomal abnormalities and mutations associated with prognosis. Because of the defined molecular and cytogenetic features, AML has been a focus of gene expression profiling studies and identified differentially expressed genes in the...

The immunomodulatory drug lenalidomide can induce striking hematologic and cytogenetic responses in patients with myelodysplastic syndromes (MDS), especially among patients whose clonal cells bear a somatic deletion of the long arm of chromosome 5q (del(5q)). Unfortunately, most patients whose cytopenias and burden of clonal cells improve during lenalidomide therapy will relapse within three ye...

BACKGROUND & OBJECTIVES Multiple myeloma (MM) is a plasma cell malignancy characterized by cytogenetic heterogeneity. In comparison with conventional karyotyping, fluorescence in situ hybridization (FISH) can efficiently detect various genetic changes in non-cycling plasma cells in 50-90 per cent of MM cases. The present study was undertaken in MM patients to evaluate the frequency and clinico-...

Triploidy is a lethal chromosomal abnormality. Foetuses with triploid condition have a tendency to die in early conception and very few survive to term. In this study, we report the prenatal diagnosis of fetal triploidy with unexpected chromosomal translocation. A 27 years old women was referred to our clinical cytogenetic department due to history of previous conceptus with intrauterine growth...