Introduction Nitric Oxide Source of NO in exhaled air Measurement Asthma COPD Cystic fibrosis Bronchiectasis Primary ciliary dyskinesia Rhinitis Interstitial lung diseases Pulmonary hypertension Occupational diseases Infections Chronic cough Lung cancer Lung transplant rejection Adult respiratory distress syndrome Diffuse Panbronchiolitis Carbon Monoxide Source of exhaled CO Measurement Asthma ...

Congenital cystic Adenomatoid malformation is a rare developmental abnormality of the lung occuring in 1-4/100000 live births.In most cases the outcome with CCAM in fetus is very good,while in some cases the outcome is very bad and can be life threatning for the fetus.we report here a case of 40 day old female infant who presented with worsening respiratory distress since birth and x ray and CT...

Pulmonary exacerbations in cystic fibrosis airways are accompanied by inflammation, neutrophilia, and mucous thickening. Cystic fibrosis sputum contains a large amount of uncleared DNA contributed by neutrophil extracellular trap (NET) formation from neutrophils. The exact mechanisms of the induction of NETosis in cystic fibrosis airways remain unclear, especially in uninfected lungs of patient...

hyper - immunoglobulin e syndrome is a rare primary immunodeficiency disease characterized by recurrent abscess formation, respiratory tract infections and very high titers of serum ige associated with peculiar face and skeletal features. we report a seven-year old  girl  presenting with persistent productive cough and  history of chronic eczematoid facial lesions since infancy  and  two episod...

The Cystic Fibrosis Transmembrane Regulator (CFTR) should no longer be viewed primarily as a ‘chloride Abstract channel’ but recognized as a channel that also controls the efflux of other physiologically important anions, such as glutathione (GSH) and bicarbonate. More effective approaches to cystic fibrosis treatment may result from this reconceptualization of the CFTR by researchers and clini...

Since the 1989 discovery that mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF), there has been substantial progress toward understanding the molecular basis for CF lung disease, leading to the discovery and development of new therapeutic approaches. However, the earliest impact of the loss of CFTR function on airway physiology and struc...

OBJECTIVE To determine the effects of respiration on the size of lung cysts by comparing inspiratory and expiratory high-resolution CT (HRCT) scans. MATERIALS AND METHODS The authors evaluated the size of cystic lesions, as seen on paired inspiratory and expiratory HRCT scans, in 54 patients with Langerhans cell histiocytosis (n = 3), pulmonary lymphangiomyomatosis (n = 4), confluent centrilo...

BACKGROUND Chronic progressive lung disease is the most serious complication of cystic fibrosis (CF). Glutathione plays an important role in the protection of the CF lung against oxidant-induced lung injury. OBJECTIVES We hypothesized that a polymorphism in a novel candidate gene that regulates glutathione synthesis might influence CF lung disease. METHODS In a cross-sectional study, subjec...

The principal clinical manifestations of cystic fibrosis are bronchiectasis with chronic pulmonary infection and pancreatic malabsorption due to destruction of the exocrine pancreas.' The interactions between the lung disease and nutrition are important because nutritional state usually parallels declining lung function and is a predictor of survival.2 A better understanding of how these two fa...

BACKGROUND Although Pseudomonas aeruginosa is the most common bacterial infection in adults with cystic fibrosis and frequently develops resistance to multiple classes of antibiotics, it has not been determined whether patients with multiple antibiotic-resistant Pseudomonas aeruginosa have worse clinical outcomes than patients with more susceptible strains. OBJECTIVES This study assessed the ...