F. Antigny and co-workers raise interesting points in their comment on the transcriptomic analysis of cystic fibrosis transmembrane conductance regulator (CFTR)-impaired endothelial cells (ECs) revealing a pro-inflammatory phenotype [1]. Indeed, CFTR impairment different models organisms, absence concomitant infection, suggests that ECs are an overlooked mediator exaggerated observed (CF). Whet...

Abstract Cystic fibrosis (CF) is characterized by an airway obstruction caused a thick mucus due to malfunctioning Fibrosis Transmembrane Conductance Regulator (CFTR) protein. The sticky restricts drugs in reaching target cells limiting the efficiency of treatments. development new approaches enhance drug delivery lungs represents CF treatment's main challenge. In this work, we report productio...

Intracellular protein traffic plays an important role in the regulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) chloride channels. Microtubule and actin-based motor proteins direct CFTR movement along trafficking pathways. As shown for other regulatory proteins such as adaptors, the involvement of protein motors in CFTR traffic is cell-type specific. Understanding motor sp...