background: acute kidney injury (aki) is a common problem in critically ill patients and is independently associated with increased morbidity and mortality. recently, serum cystatin c has been shown to be superior to creatinine in early detection of renal function impairment. we compared estimated gfr based on serum cystatin c with estimated gfr based on serum creatinine for early detection of ...

the objective of this study was to determine and compare cystatin c changes before and after radiotherapy in patients with stomach cancer who were candidate for radiotherapy. this study was conducted as a prospective cohort one. eighteen patients with definite diagnosis of stomach cancer under treatment by radiotherapy who presented to radiotherapy-oncology center of imam hossein hospital, tehr...

OBJECTIVE Overexpression of elastolytic cysteine and aspartic proteases, known as cathepsins, is implicated in atherogenesis. The potential significance of imbalance in expression between cathepsins and their inhibitor cystatin C in cardiovascular disease has been highlighted by the demonstration of cystatin C deficiency in human atherosclerosis and abdominal aortic aneurysms. METHODS AND RES...

Background Serum cystatin C has been known as a novel marker of preclinical renal dysfunction, and higher cystatin C levels are associated with increased risks of hip and nonvertebral fractures. However, there are few reports on the association between serum cystatin C and bone mineral density (BMD), especially in the Asian population. We evaluated the association between cystatin C levels and ...

Cystatin M is a secreted inhibitor of lysosomal cysteine proteases. Several lines of evidence indicate that cystatin M is a tumor suppressor important in breast malignancy; however, the mechanism(s) that leads to inactivation of cystatin M during cancer progression is unknown. Inspection of the human cystatin M locus uncovered a large and dense CpG island within the 5' region of this gene (term...

OBJECTIVE The aim of the present study was to examine serum cystatin C levels in association with the Mediterranean diet in a healthy Greek population. METHODS Cystatin C together with basic clinical chemistry tests was measured in a total of 490 adults (46±16 years, 40% of males), who underwent an annual health check. Demographic, anthropometric and lifestyle characteristics were recorded, w...

BACKGROUND Several markers are available to estimate the glomerular filtration rate (GFR) in patients. Cystatin C is a relatively new marker and has been suggested as an alternative for creatinine. Numerous studies have been performed to evaluate the usefulness of cystatin C to estimate GFR. The aim of this study is to compare the renal extraction of cystatin C with that of 125I-iothalamate in ...

Patients with chronic kidney disease (CKD) are at high risk for developing cardiovascular disease (CVD) and cardiovascular events. Cystatin C, a protease inhibitor synthesized in all nucleated cells, has been proposed as a replacement for serum creatinine for the assessment of renal function, particularly to detect small reductions in glomerular filtration rate. This report presents a review of...

BACKGROUND Contrast-induced nephropathy (CIN) frequently complicates cardiac catheterization, so the objectives of present study were to investigate the usefulness of cystatin C before catheterization and establish a cut-off level for CIN, and to examine the changes in cystatin C and several other markers in patients with and without CIN. METHODS AND RESULTS Prospective study of consecutive 8...

Objective: To investigate the association between serum cystatin C and vascular endothelial function in patients with essential hypertension. Methods: A total of 434 cases (male 228, female 206) with an average age of (56.5±12.0) years were enrolled in the first hospital of Shanxi Medical University, including 343 patients with essential hypertension and 100 patients without hypertension, rangi...