Hyperphagia was induced in mice by p.o. administration of different types of CNS depressant drugs, like chlordiazepoxide 25 mg/kg diazepam 2.5 mg/kg, cyproheptadine 2 mg/kg and phenobarbitone 25 mg/kg. Such hyperphagia was abolished by pretreatment with naloxone 0.1 mg/kg sc. Naloxone per se at this dose produced no significant effect on the food intake. This is suggestive of the role of peptid...

BACKGROUND Children with cancer frequently have associated cachexia and malnutrition. Failure to thrive affects nearly 40% of oncology patients with advanced or progressive disease. Malnutrition can erode quality of life and adversely impact disease prognosis. Appetite stimulation and increased food intake is 1 approach to combat cancer-related cachexia. MATERIALS AND METHODS Cyproheptadine h...

This case report discusses the history and management of a schizophrenic patient, a 18-year-old man, who had taken a massive overdose of clonazepam, abilify, depakote, zoloft and seroquel altogether. After discontinuation of these drugs and administration of cyproheptadine with IV fluids, he became hemodynamically stable. This case suggests that serotonin syndrome should be recognized promptly ...

bone densitometry, bone marrow biopsy) were normal. The patient was therefore diagnosed with cutaneous mastocytosis of telangiectasia macularis eruptiva perstans type and cold urticaria. At the time of writing, the patient was receiving cyproheptadine 4 mg/8 h, which partially controlled the outbreaks. Wheals continued to appear upon cold exposure, but were less severe and of shorter duration. ...

The influence of mouse genotype on passive systemic anaphylaxis (PSA) by immune complexes was studied. PSA was induced by using Brucella abortus endotoxin as the antigen and rabbit anti-Brucella endotoxin antisera. Experiments using syngeneic mice as well as mice congenic for H-2 showed that the H-2 haplotype influenced the sensitivity of mice to PSA. Among the H-2 haplotypes studied, H-2b was ...

BACKGROUND & OBJECTIVES Several studies have shown the possible analgesic effects of gabapentin, widely used as an antiepileptic. Thus, clinical studies have been carried out especially for neuropathic syndroms. This study was undertaken to investigate experimentally whether gabapentin has analgesic effects in mice and rats. METHODS The mice were divided into 10 groups (n=7) with various trea...

objective: losing weight in consequence of appetite loss can be a sign of a serious underlying condition. currently, the most widely prescribed medication for anorexia is cyproheptadine hydrochloride. however, the clinical use of cyproheptadine hydrochloride is limited by its side effects. in iranian traditional medicine, coriandrum sativum stimulates the appetite. therefore, the effect of cori...