bone densitometry, bone marrow biopsy) were normal. The patient was therefore diagnosed with cutaneous mastocytosis of telangiectasia macularis eruptiva perstans type and cold urticaria. At the time of writing, the patient was receiving cyproheptadine 4 mg/8 h, which partially controlled the outbreaks. Wheals continued to appear upon cold exposure, but were less severe and of shorter duration. ...

The influence of mouse genotype on passive systemic anaphylaxis (PSA) by immune complexes was studied. PSA was induced by using Brucella abortus endotoxin as the antigen and rabbit anti-Brucella endotoxin antisera. Experiments using syngeneic mice as well as mice congenic for H-2 showed that the H-2 haplotype influenced the sensitivity of mice to PSA. Among the H-2 haplotypes studied, H-2b was ...

BACKGROUND & OBJECTIVES Several studies have shown the possible analgesic effects of gabapentin, widely used as an antiepileptic. Thus, clinical studies have been carried out especially for neuropathic syndroms. This study was undertaken to investigate experimentally whether gabapentin has analgesic effects in mice and rats. METHODS The mice were divided into 10 groups (n=7) with various trea...

objective: losing weight in consequence of appetite loss can be a sign of a serious underlying condition. currently, the most widely prescribed medication for anorexia is cyproheptadine hydrochloride. however, the clinical use of cyproheptadine hydrochloride is limited by its side effects. in iranian traditional medicine, coriandrum sativum stimulates the appetite. therefore, the effect of cori...

The three antihistaminic drugs investigated are of diverse chemical types, and many chemical methods have been reported for their assay. Cyproheptadine hydrochloride (CPH) is a serotonin and a histamine antagonist with anticholinergic and sedative effects. It also blocks voltage sensitive calcium channels in pancreatic islet cells and smooth muscle. CPH is also used as an appetite stimulant to ...