1 Primary treatment with amphotericin B or quickly switching from azoles to amphotericin B seems to be mandatory for good clinical outcome. There is no evidence of a clear correlation between the MICs of amphotericin B and outcome of treatment , but high MICs should be taken into consideration for antifungal alternatives. 7 The combination of amphotericin B with caspofungin could have been bene...

Azole resistance in Aspergillus fumigatus isolates from the ARTEMIS global surveillance study is primarily due to the TR/L98H mutation in the cyp51A gene. reported case of azole-resistant Aspergillus fumigatus due to the TR/L98H mutation in Germany. Molecular epidemiology of Aspergillus fumigatus isolates harboring the TR34/ L98H azole resistance mechanism. expansion and emergence of environmen...

UNLABELLED A rapid and global emergence of azole resistance has been observed in the pathogenic fungus Aspergillus fumigatus over the past decade. The dominant resistance mechanism appears to be of environmental origin and involves mutations in the cyp51A gene, which encodes a protein targeted by triazole antifungal drugs. Whole-genome sequencing (WGS) was performed for high-resolution single-n...

To the Editor: We read with interest the report by van der Linden et al. about the prevalence of azole-resistant Aspergillus fumigatus isolates from 19 countries, including 2 from the Americas (Brazil and the United States) (1). Recent reports have suggested a link between use of fungicides in agricultural practices and the presence of triazole-resistant A. fumigatus among azole-naive persons (...

As triazole antifungal drug resistance during invasive Aspergillus fumigatus infection has become more prevalent, the need to understand mechanisms of resistance in A. fumigatus has increased. The presence of two erg11 (cyp51) genes in Aspergillus spp. is hypothesized to account for the inherent resistance of this mold to the triazole fluconazole (FLC). Recently, an A. fumigatus null mutant of ...