نتایج جستجو برای: cyp 3a
تعداد نتایج: 15471 فیلتر نتایج به سال:
1,2-Dichloro-3,3,4,4,5,5-hexafluorocyclopentene (F 6 cypCl 2 ) was functionalized with diphenyl- and dimesitylphosphanyl groups by a salt-elimination reaction of the respecttive chlorophosphane (PPh Cl, PMes Cl) in situ generated lithiated F cyp(Li)Cl. cyp(PR )Cl (R = Ph, Mes) functionalised again to obtain corresponding trimethylstannyl substituted compounds )(SnMe 3 Mes). These tin-precursors...
Genetically engineered bacterial cells expressing human cytochrome P450 (CYP) have been developed as new tools to predict the metabolism and toxicity of drugs in humans. There are various host cells for the heterologous expression of a form of CYP. Among them, bacterial cells such as Escherichia coli (E. coli) have advantages with regard to ease of use and high yield of protein. CYP protein cou...
در سال های اخیر، افزایش ورود آلایند های زیستی به اکوسیستم های طبیعی تبدیل به یکی از مهمترین چالش های زندگی روزمره انسان شده است. در این میان آلودگی با فلزات سنگین که عمدتاً در اثر فعالیت های صنعتی ایجاد می گردد، بدلیل ویژگی تجزیه ناپذیری زیستی و شیمیایی از خطرناکترین آلوده کننده ها بشمار می آید. در سلول های موجودات زنده بمنظور کاهش اثرات سمیت فلزات مکانیسم هایی تعبیه شده است که از جمله آن می توا...
The total content of rat liver microsomal cytochrome P450 (CYP) significantly decreased after repeated i.p. administration of the antiviral agent tenofovir ((R)-9-[2-(phosphonomethoxy)propyl] adenine) and tenofovir disoproxil at a daily dose 25 mg/kg, although the content of liver microsomal protein did not change. The decrease of the CYP content was accompanied by concomitant increase of the a...
There is an increasing demand for versatile and ubiquitous Cytochrome P450 (CYP) biocatalysts for biotechnology, medicine, and bioremediation. In the last decade there has been an increase in realization of the power of CYP biocatalysts for detoxification of soil and water contaminants using transgenic plants. However, the major limitations of mammalian CYP enzymes are that they require CYP red...
Cypermethrin (CYP) is a popular environmental toxicant because of its wide-ranging use as broad-band insecticide. The purpose this research was to explore the potential impact Moringa oleifera leaves extract (MOLE) protective agent against cypermethrin-induced lung toxicity in male albino rats. Forty experimental animals were allocated into four groups. G1 served negative control, G2, G3 and G4...
Hypertension is a leading cause of cardiovascular, cerebral, and renal disease morbidity and mortality. Here we show that disruption of the Cyp 4a14 gene causes hypertension, which is, like most human hypertension, more severe in males. Male Cyp 4a14 (-/-) mice show increases in plasma androgens, kidney Cyp 4a12 expression, and the formation of prohypertensive 20-hydroxyarachidonate. Castration...
Numerous studies have demonstrated that endocrine-disrupting compounds (EDC) are a possible cause of male reproductive organ malfunction and malformation. Cypermethrin (CYP) is a widely used synthetic pyrethroid and a potential EDC. This study aimed to examine the effects of perinatal exposure to low-dose CYP on the development and function of the offspring testes. Pregnant mice were intragastr...
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