Rationally designed nanoparticles that can bind toxins show great promise for detoxification. However, the conventional intravenous administration of nanoparticles for detoxification often leads to nanoparticle accumulation in the liver, posing a risk of secondary poisoning especially in liver-failure patients. Here we present a liver-inspired three-dimensional (3D) detoxification device. This ...

The pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide/aldophosphamide has been evaluated in 12 patients with metastatic breast cancer undergoing high-dose chemotherapy followed by bone marrow transplantation. Each patient received an initial dose of 4 g/m2 of cyclophosphamide over 90 min to prime peripheral blood progenitor cells (the first course), and 3 weeks later, 6 g/m2 of...

Cyclophosphamide is an anticancer drug with immunosuppressive activities. Considering various reports on the possible antioxidant/protective functions of ascorbic acid, it is aimed at to explore the modulatory effect of ascorbic acid on therapeutic efficacy as well as mutagenic potentials of cyclophosphamide in the same tumor bearing mice. Swiss albino mice with ascites Dalton’s lymphoma were u...

BACKGROUND Primordial follicular depletion has thought to be a common adverse effect of chemotherapy especially for female of reproductive age. The study aimed to evaluate the protective effect of rapamycin on the primordial follicles and its potential mechanism for patients receiving chemotherapy. METHODS 8-week old BALB/c female mice were randomly assigned into four groups (control; rapamyc...

Cyclophosphamide is the most commonly used alkylating agent for anti cancer chemotherapy and immunosuppression. Halothane and sevoflurane are volatile anesthetics and halothane has been demonstrated to enhance cyclophosphamide toxicity. However, the interaction between sevoflurane and cyclophosphamide has not yet been investigated. We evaluated the effects of cyclophosphamide on myocardial depr...

objective(s):gemifloxacin is a broad spectrum antibiotic and has shown excellent coverage against a wide variety of microorganisms. in this study, an attempt was made to evaluate the immunomodulatory potential of gemifloxacin in male swiss albino mice in vivo. materials and methods: three doses of gemifloxacin 25 mg/kg, 50 mg/kg and 75 mg/kg were used intraperitoneally (ip) for the evaluation o...

Background: Since the number of drug users is increasing, applying a method of detoxification with fewer side effects during withdrawal from opioids and greater reliability seems to be necessary. In addition, without maintenance treatment, there will be limited success of treatment. This study aimed to compare success rates of detoxification with sublingual buprenorphine and clonidine and to ev...