The cyclic nucleotides monophosphates (cNMP) and in particular adenosine 3’,5’-cyclic monophosphate (cAMP) and guanosine 3’,5’-cyclic monophosphate (cGMP) are cyclic catalytic products of adenosine 5'-triphosphate (ATP) and guanosine 5’-triphosphate (GTP) respectively. These cNMPs are universal second messengers with key roles in many and diverse physiological responses and processes in prokary...

Chiral oxazaborolidinium ion-catalyzed Csp(2)-H functionalization of enones using diazoacetate has been developed. Various β-substituted cyclic enones were synthesized in high yield (up to 99%) with high to excellent enantioselectivity (up to 99% ee). The synthetic utility of this reaction was demonstrated by the formal synthesis of (+)-epijuvabione.

For those who know about group cohomology will know that if a group acts freely on sphere, then it has periodic cohomology. Now the group Zp×Zp does not have periodic cohomology, (just use the Künneth formula again) therefore it cannot act freely on any sphere. For those who do not know about group cohomology a finite group having periodic cohomology is equivalent to all the abelian subgroups b...

this paper presents the results of a series of monotonic and post-cyclic triaxial tests carried out on a clay specimen and three types of clay-sand mixed specimens. the focus of the paper is on the post-cyclic mechanical behavior of the mixed specimens, as compared to their monotonic behavior. analyses of the tests results show that cyclic loading degrade undrained shear strength and deformatio...

Rat liver tyrosine aminotransferase (L-tyrosine:2oxoglutarate aminotransferase; EC 2.6.1.5.) has been studied thoroughly with respect to its inducibility by various hormones. Recently, it has been shown that this enzyme can be stimulated by cyclic AMP 1 and by theophylline 2, which is capable of elevating intracellular levels of cyclic purine nucleotides. Moreover, this enzyme was shown to be i...

Graphical Abstract The antimicrobial mode of action brevicidines. Brevicidines are potent cyclic lipopeptides active against Gram-negative pathogens. They have low hemolytic activity and cytotoxicity. BrevicidineB, a single amino acid residue mutant brevicidine, displays an altered spectrum, showing also Gram-positive Due to disruption the proton motive force pathogens, brevicidines act as bact...

mixed clayey soils occur as mixtures of sand (or gravel) and clay in widely varying proportions. their engineering behavior has not been comprehensively studied yet. an experimental program, comprising monotonic, cyclic, and post-cyclic triaxial tests was undertaken on compacted clay-granular material mixtures, having different proportions of clay and sand or gravel. this paper presents the res...

The purpose of this study was to determine whether a cyclic adenosine 3',5'monophosphate-dependent process can be involved in the regulation of vascular smooth muscle ai-adrenergic receptor responsiveness. Experiments were performed in cultured rabbit aortic smooth muscle cells which were characterized previously according to a-adrenergic receptorbinding characteristics and receptor-coupled nor...