Cutaneous drug reactions have a variety of clinical presentations. This review focuses on the most common or severe cutaneous reaction patterns. Knowledge of the clinical morphology and the most commonly associated medication aids in rapid diagnosis and institution of the appropriate therapy.

Drug hypersensitivity reactions and severe cutaneous adverse drug reactions, such as Stevens-Johnson syndrome and toxic epidermal necrolysis, are examples of serious adverse drug reactions mediated through a combination of metabolic and immunological mechanisms that could traditionally not have been predicted based on the pharmacological characteristics of the drug alone. The discovery of new a...

To investigate the epidemiology of acute cutaneous adverse drug reactions, a cross-sectional study was designed with four visits, equally distributed over one year, to all clinical departments of a large university hospital in order to find patients with possible drug-induced exanthema of less than 2 weeks' duration. Patients were examined clinically and offered investigation for possible drug ...

Chemotherapy with taxanes has recently become part of the treatment for many advanced neoplastic diseases, specially breast and lung cancer. Their main noncutaneous adverse reactions include neutropenia and mucositis, which eventually lead to drug discontinuation. Cutaneous adverse reactions are frequent and significantly interfere with the patient's quality of life. Treatments are poorly effec...

Results In total, 111 subjects were enrolled. Mean age was 39.8¡3⁄411.7 years, and male was 68.5%. The diagnoses of subjects were AS (62.2%), RA (24%), CD (17%), and pyoderma gangrenosum (0.9%). The injected agents were adalimumab (53.2%), etanercept (29%), and infliximab (20.7%). Adverse drug reactions of 30.6% were reported. The most common adverse reactions were cutaneous reactions; 10 (9.0%...

Fixed drug eruptions (FDE) are the common dermatological adverse drug reaction accounts for 16-21% of all cutaneous drug reactions in India. Drugs most frequently implicated in FDE are antimicrobials, anticonvulsants, and nonsteroidal antiinflammatory drugs. Here, we report a rare case of bullous FDE due to ciprofloxacin followed by ofloxacin administration.

AML: acute myeloid leukemia INTRODUCTION Bullous drug eruptions are cutaneous dermal hypersensitivity reactions to systemically administered medications. Classically, these eruptions appear 5 to 14 days after the initiation of the offending agent. On histopathologic examination, dermal hypersensitivity reactions are characterized by a superficial perivascular lymphocytic infiltrate, often with ...

Adverse cutaneous reactions to selective serotonin reuptake inhibitors are often mild but may nevertheless prompt drug cessation or switching, with potential loss delay of desired therapeutic effects for depression and anxiety. This case notes article presents an example sertraline-related pruritis which a precipitating cause was identified, namely chocolate, resolved simple lifestyle advice wi...