Cushing syndrome (CS) is an endocrinological disorder characterized by increased blood cortisol level. It either due to excessive endogenous release of steroids (e.g., pituitary adenoma or adrenal hyperplasia) exogenous administration steroids. Iatrogenic the most common form syndrome. The vast majority cases are oral parenteral steroid preparations, which commonly prescribed for pulmonary, ren...

Multi-secreting pituitary adenomas are relatively rare. The mixed somatotropic and corticotropic adenoma is very most widely described association that coupling hypersecretion of GH prolactin. We report the case a patient with bi-secreting ACTH. He was 28-year-old admitted for tumor syndrome, cushing syndrome. hormonal assessment found dependent ACTH other hypothalamohypophysial axes were witho...

Adrenal cortical tumors constitute a heterogeneous group of neoplasms with distinct clinical, morphological, and molecular features. Recent discoveries of specific genotype-phenotype correlations in adrenal cortical adenomas have transformed our understanding of their respective endocrine syndromes. Indeed, a proportion of patients with primary aldosteronism are now known to harbor adrenal cort...

BACKGROUND In subclinical Cushing syndrome (SC), it is assumed that glucocorticoid production is insufficient to cause a clinically recognizable syndrome. Differences in hormonal levels or recovery time of the hypothalamic-pituitary-adrenocortical (HPA) axis after adrenalectomy between patients with overt Cushing syndrome (OC) and SC remain unknown. METHODS Thirty-six patients (10 with OC and...

Cushing syndrome (CS), due to an ACTH-secreting pituitary adenoma, adrenal tumors, or ectopic ACTH secretion, causes hypercortisolism. CS is associated with major morbidity, especially metabolic and cardiovascular complications, osteoporosis, psychiatric changes, and cognitive impairment. Despite biochemical "cure" of hypercortisolism and clinical improvement after effective treatment, these co...