Os glicocorticoides (GC) exógenos foram introduzidos na prática médica por simularem a ação endógena do cortisol, o principal corticoide endógeno. Somado aos seus benefícios, os GC têm seu uso e venda permitidos sem necessidade de retenção receita e, responderem bem diversas patologias, pacientes utilizam longos períodos, conhecerem riscos que trazem para saúde. O indiscriminado apresenta um pe...

Eleven previously nonoperated patients with suspected pituitary microadenomas were scanned on a 1.5-T GE system before and after administration of IV gadolinium-DTPA (0.1 mmol/kg). Six patients had Cushing disease, four had hyperprolactinemia, and one had acromegaly. Surgical confirmation was available in all cases, and these findings were correlated with results of CT and venous sampling, when...

Chronic elevations of endogenous cortisol levels have been shown to alter medial temporal cortical structures and to be accompanied by declarative memory impairments and depressive symptoms in human adults. These effects of elevated endogenous levels of cortisol have not been directly studied in adolescents. Because adolescents with Cushing syndrome show endogenous elevations in cortisol, they ...

cushing’s syndrome (cs) occurs rarely during pregnancy. cs can be caused by prolonged abnormal exposure to excess glucocorticoids leading to special and significant signs and symptoms. it is often difficult to diagnose pathological hypercortisolism in pregnant women since some symptoms of the disease might be due to a complicated pregnancy, including preeclampsia or gestational diabetes. in thi...

pregnancy rarely occurs in untreated cases of cushing's syndrome (cs) , because most of them are infertile due to significant maternal and fetal complications during pregnancy. diagnosis of cs may be difficult during pregnancy. since physiological changes of pregnancy are overlapped by classical presentation and biological confirmation of cs. therefore the high clinical suspicious is needed for...

high cortisol level in endogenous cushing’s syndrome suppresses the immune system and after treatment there may be an over activity of immune reaction leading to autoimmune diseases mostly thyroid and rheumatologic disorders. this is the second reported case of multiple sclerosis developing after treatment of cushing’s syndrome. a 42-year old man is reported who presented with bone fracture and...

BACKGROUND AND PURPOSE Inferior petrosal sinus sampling (IPSS) is a useful diagnostic technique in adrenocorticotropic hormone (ACTH)-dependent hypercortisolism with normal or equivocal MR imaging. The procedure is believed to be safe, with mostly minor complications. However, there are rare, but severe, neurologic complications that need to be considered. MATERIALS AND METHODS We performed a...

OBJECTIVES This study was designed to evaluate left ventricular (LV) anatomy and function in patients with Cushing's syndrome. BACKGROUND A high prevalence of LV hypertrophy and concentric remodeling has been reported in Cushing's syndrome, although no data have been reported on LV systolic and diastolic function. METHODS Forty-two consecutive patients with Cushing's syndrome and 42 control...