A phytochemical investigation on the ethanolic (EtOH) extract of Vietnamese Curcuma longa (C. longa) rhizomes has led to isolation four curcuminoids including curcumin (1), demethoxycurcumin (2), bisdemethoxycurcumin (3), and cyclocurcumin (4). The chemical structure compounds 1-4 was elucidated by Nuclear magnetic resonance (NMR) Mass spectrometry (MS) spectral data. Based High-performance liq...

Plants contain numerous polyphenols, which have been shown to reduce inflammation and hereby to increase resistance to disease. Examples of such polyphenols are isothiocyanates in cabbage and broccoli, epigallocatechin in green tee, capsaicin in chili peppers, chalones, rutin and naringenin in apples, resveratrol in red wine and fresh peanuts and curcumin/curcuminoids in turmeric. Most diseases...

Curcuma longa L. rhizomes are widely used by the traditional medical practitioners for curing various diseases. The rhizomes of C. longa L. is commonly known as Haldi or Turmeric. Haldi is of special importance to human with the discovery that its rhizome powder, when added to various food preparations, preserves their freshness and imparts a characteristic flavors. The Indian system of medicin...

Turmeric is an excellent example of a plant that produces large numbers of metabolites from diverse metabolic pathways or networks. It is hypothesized that these metabolic pathways or networks contain biosynthetic modules, which lead to the formation of metabolite modules-groups of metabolites whose production is co-regulated and biosynthetically linked. To test whether such co-regulated metabo...

Abstract Background In this study, turmeric ( Curcuma longa L.) powder was prepared with various extraction and drying methods. Extractions were performed using three solvents (water, 50% ethanol, 70% ethanol) methods, namely, spray (SD), freeze (FD), spray-freeze (SFD). Results Levels of the curcuminoids, curcumin, demethoxycurcumin, bisdemethoxycurcumin, in preparations analysed HPLC, scannin...

Curcuminoid extract and piperine are being evaluated for beneficial effects in Alzheimer's disease, among other intractable disorders. Consequently, we studied the potential for herb-drug interactions involving cytochrome P450 (P450), UDP-glucuronosyltransferase (UGT), and sulfotransferase (SULT) enzymes. The curcuminoid extract inhibited SULT > CYP2C19 > CYP2B6 > UGT > CYP2C9 > CYP3A activitie...

Curcuma, a genus of rhizomatous herbaceous species, has been used as a spice, traditional medicine, and natural dye. In this study, the metabolite profile of Curcuma extracts was determined using gas chromatography-time of flight mass spectrometry (GC/TOF MS) and ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF MS) to characterize differences b...

Wound healing represents a dynamic set of coordinated physiological processes observed in response to tissue injury. Several natural products are known to accelerate the process of wound healing. Tetrahydrocurcumin (THC), an in vivo biotransformed product/metabolite of curcumin, is known to exhibit a wide spectrum of biological activities similar to those of native curcuminoids. The poor bioava...

Curcumin is one of the most intensively studied diarylheptanoid, Curcuma longa being its principal producer. This apart, a class of promising curcumin analogs has been generated in laboratories, aptly named as Curcuminoids which are showing huge potential in the fields of medicine, food technology, etc. The lack of a universal source of data on curcumin as well as curcuminoids has been felt by ...

SCOPE Curcumin revealed various health-beneficial properties in numerous studies. However its bioavailability is low due to its limited intestinal uptake and rapid metabolism. The aim of our project was to develop novel curcumin formulations with improved oral bioavailability and to study their safety as well as potential sex-differences. METHODS AND RESULTS In this crossover study, healthy s...