background: organophosphorus pesticides has been widely used in agriculture fields to control various crop insects and their extensive use pose human life at threat because of their adverse effects on human health. in this study, we checked the effects of gst polymorphism on ameliorative effect of curcumin and carvacrol against dna damages. methods: comet assay was used to assess the dna damage...

Curcumin and quercetin are natural compounds with a wide spectrum of activities, including antioxidant and anticancer activities. In this study, the combined effect of the two compounds was investigated, with special emphasis on the pharmacokinetics of curcumin by the quercetin-induced changes in the albumin binding of curcumin. We evaluated the effect of quercetin on the binding of curcumin to...

objective: this study was designed to investigate the antinociceptive effect of curcumin in diabetic rats by using the formalin and hot tail immersion tests. methods: wistar rats were divided into the following six groups:  control; curcumin-treated control (50 mg/kg); diabetic; sodium salicylate (ss)-treated diabetic; and two curcumin-treated diabetic groups (10 and 50 mg/kg). curcumin was ad...

Pendahuluan: Kanker paru merupakan kanker dengan insiden paling tinggi dan menyebabkan mortalitas yang signifikan pada pria. Leptin, sitokin derivat adiposit, memainkan peran penting proses karsinogenesis paru. Kurkumin silibinin adalah komponen herbal alami karakteristik antikanker bersifat multitarget. Diskusi: Teknologi nanopartikel magnetik (Fe3O4) memiliki sifat super-paramagnetik unik, se...

Hyperacidity in the stomach is known to promote the progression of gastric cancer. The plant-derived chemotherapeutic curcumin is used to treat gastric cancer. The objective of this study was to investigate whether curcumin regulates gastrin-mediated acid secretion in suppressing gastric cancer. Gastric cancer cells were treated with 25 μm curcumin, followed by Annexin V/propidium iodide double...

BACKGROUND/OBJECTIVES Turmeric and its active component curcumin have received considerable attention due to their many recognized biological activities. Turmeric has been commonly used in food preparation and herbal remedies in South Asia, leading to a high consumption rate of curcumin in this region. However, the amount of curcumin in the Korean diet has not yet been estimated, where turmeric...

PURPOSE Curcumin is a hydrophobic polyphenol isolated from dried rhizome of turmeric. Clinical usefulness of curcumin in the treatment of cancer is limited due to poor aqueous solubility, hydrolytic degradation, metabolism, and poor oral bioavailability. To overcome these limitations, we proposed to fabricate curcumin-piperine, curcumin-quercetin and curcumin-silibinin loaded polymeric nanoform...

background: curcumin has shown to affect sperm motility and function in vitro and fertility in vivo. the molecular mechanism(s) by which curcumin affects sperm motility has not been delineated. since modulation of intracellular ph (phi) and plasma membrane polarization is involved in sperm motility, the present study was conducted to investigate the effect of curcumin on these sperm (human and ...

Wound healing is a complex multifactorial process that relies on coordinated signaling molecules to succeed. Epidermal growth factor (EGF) is a mitogenic polypeptide that stimulates wound repair; however, precise control over its application is necessary to reduce the side effects and achieve desired therapeutic benefits. Moreover, the extensive oxidative stress during the wound healing process...

Ample attention has focused on cancer drug delivery via prodrug nanoparticles due to their high drug loading property and comparatively lower side effects. In this study, we designed a PEG-DOX-Cur prodrug nanoparticle for simultaneous delivery of doxorubicin (DOX) and curcumin (Cur) as a combination therapy to treat cancer. DOX was conjugated to PEG by Schiff's base reaction. The obtained prodr...