Circulating tumour cells (CTCs) are independent predictor of prognosis in metastatic breast cancer. Nevertheless, in one third of patients, circulating tumour cells are undetected by conventional methods. Aim of the study was to assess the prognostic value of circulating tumour cells expressing mesenchymal markers in metastatic breast cancer patients. We isolated CTC from blood of 55 metastatic...

Although circulating tumor cell (CTC) enumeration in peripheral blood has already been validated as a reliable biomarker in predicting prognosis in metastatic castration-resistant prostate cancer (mCRPC), patients with favorable CTC counts (CTC < 5/7.5 ml) still experience various survival times. Assays that can reduce patients' risks are urgently needed. In this study, we set up a real-time qu...

BACKGROUND Computed tomographio colonography, also known as virtual colonoscopy, is a rapid, non-invasive imaging technique to detect colorectal masses and polyps that is becoming increasingly popular. OBJECTIVES To evaluate the availability, technique, standards of performance and indications for CT colonography in Israel. METHODS A questionnaire on CT colonography was sent to all radiolog...

Concomitant with the rapidly growing number of treatment options for patients with metastatic carcinomas is the need for biomarkers to guide and monitor their use. Tumor cells shed into the blood during metastasis may help meet this need by serving as generic biomarkers for a variety of carcinomas. Indeed, assessment of circulating tumor cells (CTC) has already been shown to provide prognostic ...

The 5-cyano-2,3-ditolyl tetrazolium chloride (CTC) staining method is commonly and increasingly used to detect and to enumerate actively respiring cells (CTC+ cells) in aquatic systems. However, this method remains controversial since some authors promote this technique while others pointed out several drawbacks of the method. Using flow cytometry (FCM), we showed that CTC staining kinetics var...

BACKGROUND Breast cancer (BC) is the most common malignant tumor in females. This study investigated the role and utility of CTC monitoring in evaluating the prognosis of triple-negative breast cancer patients. MATERIAL AND METHODS We enrolled 286 female triple-negative breast cancer patients who were diagnosed at and received radical resection surgery in our hospital. Peripheral venous blood s...

OBJECTIVE To determine the diagnostic accuracy of computed tomography colonography (CTC) compared with conventional colonoscopy (CC). METHODS Patients with an indication of CC were included. Fifty patients underwent CTC using multidetector CT before diagnostic colonoscopy was performed by an expert colonoscopist. Diagnostic accuracy was assessed individually both for each polyp and for each p...

OBJECTIVE Although counting of circulating tumour cells (CTC) has attracted a broad interest as potential markers of tumour progression and treatment response, the lack of functional characterisation of these cells had become a bottleneck in taking these observations to the clinic. Our objective was to culture these cells in order to understand them and exploit their therapeutic potential to th...

CTC is a toy cipher designed by Courtois in order to prove the strength of algebraic attacks. In this paper we study the differential and the linear behavior of the 85 S-boxes version, which is attacked using algebraic techniques faster than exhaustive key search. We show that an n-round variant of the cipher can be attacked by a linear attack using only 2 known plaintexts, with a negligible ti...

We have previously demonstrated the increased metastatic potential of human prostate cancer circulating tumor cells (CTC), compared to their parental cells, in both orthotopic mouse models and the chick embryo model. In the current study, we asked whether an extracellular matrix (ECM), produced by human foreskin fibroblasts in culture, could inhibit PC-3 human prostate cancer CTC metastasis in ...