3- O -Sulphogalactosylceramide (sulphatide) is a major lipid component of myelin membranes, and is required for proper myelin formation. Sulphatide is synthesized in the Golgi apparatus by galactosylceramide sulphotransferase (CST; EC 2.8.2.11). Murine and human CSTs contain two putative N-glycosylation sites (Asn-66 and Asn-312). The second site is conserved among all galactose 3-O-sulphotrans...

This article explores the need for research into patient safety in large-scale Telehealth systems faced with the perspective of its development extended to healthcare systems. Telehealth systems give rise to significant advantages in improving the quality of healthcare services as well as bringing about the possibility of new types of risk. A theoretical framework is proposed for patient safety...

OBJECTIVE The Clinical Support Tools (CSTs) were developed to help therapists organize and target potential problems that might account for negative outcomes in psychotherapy. The core of CST feedback is the Assessment for Signal Clients. The purpose of this study was to describe and identify patterns of problems that typically characterize off-track cases. METHOD The responses and scores fro...

BACKGROUND AND PURPOSE Little is known about differences in corticospinal tract fibers according to cerebral origin. Using diffusion tensor tractography, we attempted to investigate the characteristics of the CST according to the cerebral origin in the human brain. MATERIALS AND METHODS Thirty-six healthy subjects were recruited for this study. A 1.5T Gyroscan Intera system was used for acqui...

Abstract Aims Drivers at Work (DW) and Learning Styles (LS) refer to a range of contentious theories that aim account for differences in career progression, yet seldom feature training assessment. This study aimed quantify the influence Core Surgical Trainees’ (CST) DW LS on progression. Methods Kolb inventories were distributed 168 CSTs during five consecutive induction boot camps single Statu...

Background and purpose Despite advances in endovascular therapies, some patients experience vertebral artery stenosis or subclavian occlusion may not benefit from less-invasive angioplasty/stenting. This study described 4 cases which carotid-vertebral transposition (CVT) carotid-subclavian (CST) was adapted when treatment unfeasible unsuccessful. Presentation Case 1: A 65-year-old woman present...

BACKGROUND AND PURPOSE Little is known about the fate of the injured CST for a large number of patients with ICH. Using DTT, we investigated the longitudinal changes of injured CSTs in patients with an ICH. MATERIALS AND METHODS We recruited 45 patients with CST injury by an ICH in the supratentorial subcortical area. Two longitudinal DTTs were acquired: 1 within 30 days and the other after 3...

Fine finger and hand movements in humans, monkeys, and rats are under the direct control of the corticospinal tract (CST). CST lesions lead to severe, long-term deficits of precision movements. We transected completely both CSTs in adult rats and treated the animals for 2 weeks with an antibody that neutralized the central nervous system neurite growth inhibitory protein Nogo-A (mAb IN-1). Anat...

The empirical literature pertaining to anxiety and related disorders in African Americans continues to be sparse, raising significant doubt upon the valid assessment of anxiety and related disorders in African American samples. The identification of culturally valid instruments that accurately identify the symptomatology associated with anxiety and related constructs as well as differentiating ...

We present a new algorithm for simulating two-fluid gas and dust mixtures in Smoothed Particle Hydrodynamics (SPH), systematically addressing a number of key issues including the generalised SPH density estimate in multi-fluid systems, the consistent treatment of variable smoothing length terms, finite particle size, time step stability, thermal coupling terms and the choice of kernel and smoot...