نتایج جستجو برای: cryptolepine isosteres
تعداد نتایج: 248 فیلتر نتایج به سال:
Bicyclo[1.1.1]pentylamines (BCPAs) are of growing importance to the pharmaceutical industry as sp3-rich bioisosteres anilines and N-tert-butyl groups. Here we report a facile synthesis 1,3-disubstituted BCPAs using twofold radical functionalization strategy. Sulfonamidyl radicals, generated through fragmentation ?-iodoaziridines, undergo initial addition [1.1.1]propellane afford iodo-BCPAs; new...
Phenols are attractive starting materials for organic synthesis due to their availability from both petrochemical and renewable sources, and their ubiquity in natural products and biologically active molecules. Nevertheless, direct methods for their functionalization often suffer from poor selectivity or poor atom-economy. This presentation will describe recent efforts from our group to develop...
Synthesis of 8-phosphorus substituted isosteres of purine [pyrimidino (4,5-d)-1,3,2-diazaphosphole], 1-deazapurine [pyridino (2,3-d)-1,3,2-diazaphosphole] and 3-deazapurine [pyridino (4,5-d)-1,3,2-diazaphosphole] has been achieved by the reaction of equimolar amounts of triphenylphosphite and 4,5-diaminopyrimidine, 2,3-diaminopyridine and 3,4-diaminopyridine, respectively. These compounds hydro...
Obesity and metabolic syndrome, along with drug dependence (nicotine, alcohol, opiates), are two of the major therapeutic applications for CB(1) cannabinoid receptor antagonists and inverse agonists. In the present study, we report the synthesis and structure-affinity relationships of 1,5-diphenylimidazolidine-2,4-dione and 1,3,5-triphenylimidazolidine-2,4-dione derivatives. These new 1,3,5-tri...
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