Cryptogenic multifocal ulcerous stenosing enteritis is a rare idiopathic disease of the small bowel. Its origin and pathophysiology have not been established. Clinicopathologic features include unexplained small bowel strictures with superficial ulceration, chronic or relapsing occlusion episodes. A 44-year-old man complained of recurrent colicky abdominal pain and dizziness. Laboratory tests i...

BACKGROUND Celiac disease (CD) is predominant in women and young people. Atypical, non-enteric symptoms are more common among adults. There is also an association between CD and neurological disorders, especially with cerebellar ataxia, polyneuropathy and epilepsy. AIM To study the frequency of CD in a group of adults with cryptogenic epilepsy. MATERIAL AND METHODS Twenty one patients with ...

Embolic strokes of undetermined source comprise a subset of cryptogenic ischemic strokes. It is thought that some embolic strokes of undetermined source could be due to left atrial thromboembolism without atrial fibrillation. The authors sought to determine whether a marker of left atrial pathological changes could pose as a surrogate marker of nonarrhythmogenic atrial thromboembolism in emboli...

BACKGROUND We hypothesized that hidden malignancy could be detected in patients with cryptogenic stroke without active cancer when they showed the distinctive characteristics of cancer-related stroke. METHODS AND FINDINGS Among 2,562 consecutive patients with acute ischemic stroke, patients with cryptogenic stroke were analyzed and categorized into two groups according to the presence of acti...

Embolic strokes of undetermined source comprise a subset of cryptogenic ischemic strokes. It is thought that some embolic strokes of undetermined source could be due to left atrial thromboembolism without atrial fibrillation. The authors sought to determine whether a marker of left atrial pathological changes could pose as a surrogate marker of nonarrhythmogenic atrial thromboembolism in emboli...

BACKGROUND Cirrhosis is one of the most severe liver complications, with multiple etiologies. The torque teno virus (TTV), also known as transfusion transmitted virus, which has a high incidence in the world population, is one of the possible increasing risk factors in patients with idiopathic fulminant hepatitis and cryptogenic cirrhosis. OBJECTIVES The aim of this study was to evaluate soli...

BACKGROUND The reasons why cryptogenic fibrosing alveolitis has emerged as a new clinical entity during the second half of the 20th century are unclear. Some environmental exposures have been identified as potential risk factors including occupational dust, cigarette smoking and antidepressants, but there have been no studies of the role of early life exposures. Since adult height reflects, in ...

A growing number of published papers consider the nonalcoholic fatty liver disease (NAFLD) and cryptogenic cirrhosis as the immediate offspring of Type 2 diabetes mellitus (T2DM). NAFLD is the most common liver disorder in developed countries, where up to 80% of obese people have the disease. Cirrhosis is defined as the advanced stages of hepatic fibrosis with characteristic distortion of hepat...

Background: Approximately 25% of strokes are cryptogenic in origin and identifying atrial fibrillation (AF) as an etiologic factor in this situation has major therapeutic implication. Standard Holter ECG has a low sensitivity for AF detection in this patient group. Aim: To assess the diagnostic yield of prolonged ambulatory noninvasive ECG telemonitoring for AF detection in cryptogenic stroke o...

Background There are few data on the mechanism of recurrent neurological events after transcatheter closure of patent foramen ovale (PFO) in cryptogenic stroke or TIA. Methods We retrospectively reviewed PFO closure procedures for the secondary prevention of cryptogenic stroke/TIA performed between 1999 and 2014 in Bologna, Italy. Results Written questionnaires were completed by 402 patient...