Patients with mantle cell lymphoma (MCL) generally respond to first-line immunochemotherapy, but often show chemoresistance upon subsequent relapses, with poor outcome. Several studies of the immunomodulator, lenalidomide, have demonstrated its activity in MCL including the MCL-001 study in relapsed/refractory patients who had failed defined prior therapies of anthracyclines or mitoxantrone, cy...

We have used optical interferometry to obtain multi-wavelength visibility curves for eight red giants over the wavelength range 650–1000 nm. The observations consist of wavelengthdispersed fringes recorded with MAPPIT (Masked APerture-Plane Interference Telescope) at the 3.9-m Anglo-Australian Telescope. We present results for four Miras (R Car, o Cet, R Hya, R Leo) and four semi-regular variab...

Anti-ulcer potential and proton pump inhibitory activity of kolaviron (KV) isolated from Garcinia kola Heckel has been evaluated using different ulcer models. Cold-restraint (CRU), aspirin (ASP), alcohol (AL), pyloric ligation (PL) induced gastric ulcer models were used to assess anti-ulcerogenic activity of KV in rats. Effects of KV on gastric juice for free and total acidity, peptic activity ...

Introduction Cardiac excitation–contraction coupling is a transduction cascade that results in muscle contraction and relaxation. In ventricular myocytes, the arrival of an action potential activates sarcolemmal L-type Ca channels, and the subsequent inward Ca current, in turn, activates several RyRs in the SR membrane (the Ca release unit [CRU]). Activation of a CRU causes more Ca to be releas...

The most frequently used climate classification map is that of Wladimir Köppen, presented in its latest version 1961 by Rudolf Geiger. A huge number of climate studies and subsequent publications adopted this or a former release of the Köppen-Geiger map. While the climate classification concept has been widely applied to a broad range of topics in climate and climate change research as well as ...

Introduction Cardiac excitation–contraction coupling is a transduction cascade that results in muscle contraction and relaxation. In ventricular myocytes, the arrival of an action potential activates sarcolemmal L-type Ca channels, and the subsequent inward Ca current, in turn, activates several RyRs in the SR membrane (the Ca release unit [CRU]). Activation of a CRU causes more Ca to be releas...

One of key inputs to hydrological modeling is the potential evapotranspiration, either from the interception (PET0) or from the soil water of root zone (PET). The Shuttleworth–Wallace (S–W) model is developed for their estimation. In this parameterization, neither experimental measurement nor calibration is introduced. Based on IGBP land cover classification, the typical thresholds of vegetatio...

Previous studies demonstrated that vaccination-induced tumor-specific immune response is associated with superior clinical outcome in patients with follicular lymphoma. Here, we investigated whether this positive correlation extends to overall survival (OS). We analyzed 91 untreated patients who received CVP chemotherapy (cyclophosphamide, vincristine, and prednisone) followed by idiotype vacci...

Introduction Cardiac excitation–contraction coupling is a transduction cascade that results in muscle contraction and relaxation. In ventricular myocytes, the arrival of an action potential activates sarcolemmal L-type Ca channels, and the subsequent inward Ca current, in turn, activates several RyRs in the SR membrane (the Ca release unit [CRU]). Activation of a CRU causes more Ca to be releas...

O leite é considerado uma boa fonte de nutrientes, pois contém macro e micronutrientes. Porém mesmo ele sendo um dos principais alimentos para os seres humanos, torna-se excelente substrato o crescimento desenvolvimentos vários patógenos. Portanto, deve ser obtido da forma mais higiênica mantido refrigerado, desde a ordenha até processamento, garantir qualidade suas propriedades físicas, químic...