difficulty in swallowing (dysphagia) is common among all age groups, especially in elderly and children. orally disintegrating tablets constitute an innovative dosage form that overcomes the problems of swallowing and provides a quicksetof action. the purpose of this study was to formulate and evaluate an orally disintegrating tablet (odt) containing captopril while using croscarmellose sodium,...

the aim of this study was to design orally disintegrating tablets of olanzapine and to complex olanzapine with 2-hydroxypropyl-β- cyclodextrin with special emphasis on disintegration and dissolution studies. phase solubility studies demonstrated the formation of 1:1 molar inclusion complex by kneading method. tablets were prepared by using superdisintegrants namely, sodium starch glycolate, cro...

The hydrophobicity of poorly soluble drugs can delay tablets disintegration. We probed here the influence different disintegrants on disintegration challenging hydrophobic formulations. Tablets containing diluents, hydrogenated vegetable oil and either sodium starch glycolate (SSG), croscarmellose (CCS) or crospovidone (XPVP) were prepared. time was tested immediately after storage at 40 °C 75%...

Since orally disintegrating tablets (ODTs) of tramadol hydrochloride are not available in the market, so an attempt has been taken to formulate and evaluate ODT preparation hydrochloride. In this present work, direct compression was technique used for preparing using superdisintegrants like croscarmellose sodium, sodium starch glycolate crospovidone at different concentrations. Prepared formula...

Both the Valsartan (VAL) and Olmesartan medoxomil (OLM) are widely prescribed anti-hypertensive agents with angiotensin II type I receptor antagonistic activity. VAL OLM of BCS class drugs having a low variable oral bioavailability. Recrystallization from different organic solvents improved its aqueous solubility thereby in vitro dissolution properties. In present investigation, tablets contain...

The aim of this study was to evaluate the effect three coformers and five disintegrants in granulation formulation on dissociation cocrystal during process by monitoring wet with probe-type low-frequency Raman (LF-Raman) spectroscopy. As model cocrystals, paracetamol (APAP)-oxalic acid (OXA), APAP-maleic (MLA), APAP-trimethylglycine (TMG) were used. recipe containing cocrystals performed over t...

Oral dispersible tablets (ODTs) are patient friendly dosage form that rapidly disintegrate or dispersed in mouth without the need of water. In the present investigation eight ODT formulations of zidovudine, an antiretroviral drug, were prepared using different superdisintegrants viz. Crospovidone (PPXL), Crosscarmellose sodium (Ac-di-sol) and sodium starch glycollate by direct compression metho...