White adipose tissue (WAT), one of two types of adipose tissue found in mammals, is critical for energy storage in times when food sources are scarce. Too much WAT, however, evokes an inflammatory response that can lead to metabolic and cardiovascular disorders. This response is, in part, regulated by nuclear receptors found within the adipocyte and infiltrating adipose tissue macrophages. In t...

BACKGROUND Allograft inflammatory factor 1 (AIF-1) is a putative obesity gene. Our aim was to examine the expression of AIF-1 in human white adipose tissue (WAT) in relation to obesity and metabolic phenotypes in women. METHODS WAT secretion of AIF-1 was determined in subcutaneous adipose tissue pieces in vitro by ELISA from 5 subjects. mRNA expression of AIF-1 was determined by RT-qPCR in th...

Critically ill pediatric patients frequently receive prolonged analgesia and sedation to provide pain relief and facilitate intensive care therapies. Iatrogenic withdrawal syndrome occurs when these drugs are stopped abruptly or weaned too rapidly. We investigated the validity and generalizability of the Withdrawal Assessment Tool-1 (WAT-1) in children during weaning of analgesics and sedatives...

In April 1982 is aangekondig dat in beginsel goedgekeur is dat verpleegkolleges met universiteite kan affilieer. Hierdie aankondiging was die kulminasie van ’n stryd wat die verpleegberoep in Suid-Afrika byna ’n eeu lank gevoer het om verpleegonderwys in die hoofstroom van die land se hoer onderwysstelsel geplaas te kry. Dit is een van die belangrikste onlangse ontwikkelings in verpleging en di...

OBJECTIVE The aim of this study was to correlate specific fatty acid profiles of visceral white adipose tissue (WAT) with inflammatory signatures potentially associated with colorectal cancer (CRC). METHODS Human adipocytes were isolated from biopsies of visceral WAT from 24 subjects subdivided in four groups: normal-weight (BMI 22.0-24.9 Kg/m2) and over-weight/obese (BMI 26.0-40.0 Kg/m2), af...

Obesity is currently a serious worldwide public health problem, reaching pandemic levels. For decades, dietary and behavioral approaches have failed to prevent this disease from expanding, and health authorities are challenged by the elevated prevalence of co-morbid conditions. Understanding how obesity-associated diseases develop from a basic science approach is recognized as an urgent task to...

Although fish oil has hypolipidemic and antiatherosclerotic properties, the potential for white adipose tissue (WAT) to mediate these effects has not been studied. LDL-receptor deficient (LDLR-/-) mice were fed high fat, olive oil-containing diets supplemented with additional olive oil or with fish oil for 12 wk. Fish oil feeding significantly reduced plasma lipid levels. In contrast, lipid sto...