Lung tissue from 221 definite and probable cases of malignant mesothelioma reported to the Australian Mesothelioma Surveillance Program from January 1980 through December 1985 and from an age-sex frequency matched control series of 359 postmortem cases were examined by light microscopic (LM) and analytical transmission electron microscopic (TEM) analysis and energy dispersive x-ray analysis (ED...

A number of proliferativiand cytotoxic responses similar to those induced by classical tumor promoters such as 12-0-tetradecanoylphorbol13-acetate occur in trachea! epithelial cells and organ cultures exposed to asbestiform minerals. In these studies, cloned diploid hamster trachea! epithelial cells were examined in a number of short term (3-24 h) and long term (>24 h) biological assays for the...

Asbestos is an important environmental carcinogen in the United States and remains the primary occupational concern in many developing countries; however, the underlying mechanisms of its genotoxicity are not known. We showed previously that asbestos is a potent gene and chromosomal mutagen in mammalian cells and that it induces mostly multilocus deletions. Furthermore, reactive oxygen species ...

OBJECTIVES Mounting evidence suggests that asbestos fibres can stimulate alveolar macrophages to generate the potent inflammatory and fibrogenic mediator, tumour necrosis factor-alpha (TNF-alpha), and that this may play an important part in the onset and development of airway inflammation and lung fibrosis due to asbestos fibre inhalation. Little is known, however, about the ability of other mi...

in 2007, research was carried out to determine the type and amount of asbestos fibers in a croatian factory with a long history of making asbestos-containing products.since the 1970s, asbestos fibres have been considered carcinogenic in humans i.e as a known cancer-causing agent. in the environment, asbestos fibres are inactive and naturally resist biodegradation. in time, fibres can only be gr...

unsafe ground in relying heavily on a single, relatively short period, occupational hygiene survey of the Wittenoom crocidolite mine and mill' in formulating various models relating risk for asbestos diseases and airborne exposure levels. When he retired in 1984 Major gave me the long running thermal preci-pitator slides that formed the basis for the estimates of exposure for the few occupation...

Mesothelioma: Global Incidence and Relationship with Asbestos 1). The authors conclude that for very large parts of the world, data on mesothelioma incidence/mortality are not available and this constitutes a serious obstacle to the progress of knowledge of mesothelioma. No data was available from South Africa or Sub-Saharan Africa. The African continent was represented with data from Morocco a...

Editorial Mesotheliomas, minerals, and man-made mineral fibres In spite of much research and frequent international meetings no clear advice can yet be given on the prevention of mesotheliomas. After the original observations of Wagner et al,' the evidence from South Africa has been consistent with t'he view that only crocidolite causes meso-thelioma. Although conditions in the African chrysoti...