AIMS To determine the effect of trophic feeding on clinical outcome in ill preterm infants. METHODS A randomised, controlled, prospective study of 100 preterm infants, weighing less than 1750 g at birth and requiring ventilatory support and parenteral nutrition, was performed. Group TF (48 infants) received trophic feeding from day 3 (0.5-1 ml/h) along with parenteral nutrition until ventilat...

The Saccharomyces cerevisiae kinase Ste20 is a member of the p21-activated kinase (PAK) family with several functions, including pheromone-responsive signal transduction. While PAKs are usually activated by small G proteins and Ste20 binds Cdc42, the role of Cdc42-Ste20 binding has been controversial, largely because Ste20 lacking its entire Cdc42-binding (CRIB) domain retains kinase activity a...

Objective: To depict the magnitude and spectrum of childhood injuries attributable to falls from bunk beds in comparison with conventional beds and to outline sociodemographic risk factors and injury characteristics. Study design: Case-control investigation. Setting: Accident and emergency departments of four hospitals in Greece, namely a teaching children’s hospital and a trauma hospital in Gr...

Purpose: Document indicators of an increased risk to develop retinopathy of prematurity (ROP) in low birth weight (LBW, < 1500g) infants. Methods: Retrospective chart review. Neonatal characteristics collected were birth weight, gestational age (GA), CRIB (Clinical Risk Index for Babies) score, Apgar score and indicators of respiratory, circulatory and renal instability. Small for gestational a...

OBJECTIVES To evaluate and compare birthweight and scores as predictors of neonatal mortality in a Neonatal Intensive Care Unit (NICU). METHODS The survey included 494 newborns admitted to the neonatal intensive care unit (NICU) of a general hospital in Porto Alegre, southern Brazil, immediately after delivery, between March 1997 and June 1998. Birthweight and scores were evaluated in terms o...

BACKGROUND There is controversy over whether improved survival of preterm infants has resulted in a higher incidence of severe (grade 3 or greater) retinopathy of prematurity (ROP). AIM To compare survival rates and rates of > or = stage 3 ROP-that is, with a high risk of sequelae-in preterm infants in five English cities where, anecdotally, the incidence of ROP is reported to show considerab...

INTRODUCTION Pain management and sedation is a priority in neonatal intensive care units. A study was designed with the aim of determining current clinical practice as regards sedation and analgesia in neonatal intensive care units in Spain, as well as to identify factors associated with the use of sedative and analgesic drugs. METHOD A multicenter, observational, longitudinal and prospective...

Running title: PAK control of chemotaxis 2 SUMMARY We have identified a new Dictyostelium p21-activated protein kinase, PAKc, that we demonstrate to be required for proper chemotaxis. PAKc contains a Rac-GTPase binding (CRIB) and autoinhibitory domain, a PAK-related kinase domain, an N-terminal phosphatidylinositol binding domain, and a C-terminal extension related to the Gβγ binding domain of ...

Background—There is controversy over whether improved survival of preterm infants has resulted in a higher incidence of severe (grade 3 or greater) retinopathy of prematurity (ROP). Aim—To compare survival rates and rates of > stage 3 ROP—that is, with a high risk of sequelae—in preterm infants in five English cities where, anecdotally, the incidence of ROP is reported to show considerable vari...

OBJECTIVE To determine if the presence of a neonatal surgical facility on site has any effect on mortality and morbidity of very premature infants with necrotising enterocolitis (NEC). DESIGN AND SETTING Retrospective review of infants of less than 29 weeks gestation cared for in the seven perinatal centres in New South Wales. PATIENTS Between 1992 and 1997, 605 infants were cared for in tw...