Molecular Modeling of the Metabolism of Acetaminophen and Acetaminophen-like Molecules by Laura Rebecca Hofto Paracetamol, or acetaminophen, is a common analgesic and fever-reducer. There are three major metabolic pathways for acetaminophen in the liver. The final products of each pathway are nontoxic and are excreted by the kidneys. Cresol and similar molecules are competitors with acetaminoph...

The Olive tree (Olea europaea L.), a native of the Mediterranean basin and parts of Asia, is now widely cultivated in many other parts of the world for production of olive oil and table olives. Olive is a rich source of valuable nutrients and bioactives of medicinal and therapeutic interest. Olive fruit contains appreciable concentration, 1-3% of fresh pulp weight, of hydrophilic (phenolic acid...

Pseudomonas alcaligenes NCIMB 9867 (strain P25X) produces isofunctional enzymes of the gentisate pathway that enables the degradation of xylenols and cresols via gentisate. Previous reports had indicated that one set of enzymes is constitutively expressed whereas the other set is strictly inducible by aromatic hydrocarbon substrates. The gene encoding gentisate 1,2-dioxygenase (GDO), the enzyme...

The xylT gene product, a component of the xylene catabolic pathway of Pseudomonas putida mt2, has been recently characterized as a novel [2Fe-2S] ferredoxin which specifically reactivates oxygen-inactivated catechol 2,3-dioxygenase (XylE). In this study, three XylT-like proteins potentially involved in the catabolism of naphthalene (NahT) or cresols (PhhQ and DmpQ) have been overexpressed in Es...

Ethnopharmacological relevance: Tricresol formalin is composed of 90% formaldehyde and 10% cresols, highly volatile, has action at a distance, been used in endodontics since the 20th century, it remains widely Brazil dental treatments, necrotic teeth with periapical lesions. However, there still controversy regarding biological compatibility under conditions clinical use this drug, as studies c...

AIMS Cresols are present in antiseptics, coal tar, some resins, pesticides, and industrial solvents. Cresol intoxication leads to hepatic injury due to coagulopathy as well as disturbance of hepatic circulation in fatal cases. Patients with uremia suffer from cardiovascular complications, such as atherosclerosis, thrombosis, hemolysis, and bleeding, which may be partly due to p-cresol toxicity ...

To cite: Liu LR, Huang M-Y, Huang S-T. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2013200771 DESCRIPTION A 61-year-old man, without previous disease was admitted to our emergency department (ED) due to syncope at home after soaking his feet in a solution containing 50% of saponated cresol. On physical examination, the patient was lethargic with a strong medic...