نتایج جستجو برای: creb1

تعداد نتایج: 411  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2000
K Juarez H Flores S Dávila L Olvera V González E Morett

offhough the concept of domain merging and shuffling as a major force in protein evolution is well established, it has been difficult to demonstrate how domains coadapt. Here we show evidence of coevolution of the Sinorhizobium meliloti NifA (SmNifA) domains. We found that, because of the lack of a conserved glycine in its DNA-binding domain, this transactivator protein interacts weakly with th...

Journal: :American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2009

2016
Jaroslav Malina Michael J. Hannon Viktor Brabec

The interaction between the HIV-1 transactivator protein Tat and TAR (transactivation responsive region) RNA, plays a critical role in HIV-1 transcription. Iron(II) supramolecular helicates were evaluated for their in vitro activity to inhibit Tat-TAR RNA interaction using UV melting studies, electrophoretic mobility shift assay, and RNase A footprinting. The results demonstrate that iron(II) s...

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