The study was conducted to screen for the phytochemicals constituents of bark of Saraca asoca (Roxb.), one of the folk medicinal plants found in West Bengal, Bangladesh and Sri Lanka. The acute and subacute toxicity of methanolic extract of S. asoca bark on mice was studied. Phytochemical analysis of S. asoca (bark) methanolic extract revealed the presence of high percentage of flavonoids and r...

The sarcoidosis is a systemic granulomatosis affecting most frequently the lungs and the mediastinum. An acute renal failure reveals exceptionally this disease. It’s a retrospective study implicating 13 cases of sarcoidosis complicated of acute renal failure. The aim of this study is to determine epidemiological, clinical, biological and histological profile in these cases and the interest of c...

AIMS To study the association between peripheral blood metabolic and inflammatory factors and presence of diabetic macular edema (DME) and its related anatomic features in type 2 diabetic mellitus (T2DM) patients. MATERIAL AND METHODS Observational cross-sectional study on a proof of concept basis. Seventy-six T2DM included patients were divided based on the presence (n = 58) or absence of DM...

OBJECTIVES Leptin exerts various effects on appetite and body weight. Disruption of the obesity gene is precedent to fatness. Insulin or glucose elevates leptin, but streptozotocin reduces it. However, controversial data exist for the effects of leptin on diabetes and leptin level in each gender. Leptin can damage the kidney function but little evidence exists for its hepatic effects. The aim o...

Adverse health effects can result from occupational exposure to dust, fine particles, or toxic substances. Accumulating evidence demonstrates that particulate air pollutants can cause both pulmonary and airway inflammation. The aim of the paper was to perform an exploratory study on peripheral whole-blood using Luminex® 200TM xMAP (multi-analyte profiling) technology to analyze early effects of...

This study was designed to evaluate the protective effect of nebivolol, beta-1 blocker, on the nephrotoxicity induced by gentamicin in male albino rats. The protective effect of silymarin, as natural antioxidant, and acetylcystein, as nephroprotective agent were compared. The results revealed that three weeks of nebivolol administration prior to gentamicin, protected the rats from the oxidative...

The peritoneal generation of arachidonic acid metabolites was studied in eight patients with end-stage renal disease undergoing continuous ambulatory peritoneal dialysis (CAPD) during infection-free periods and during bacterial peritonitis. The prostacyclin metabolite 6-keto-PGF1 alpha was found to be the major prostanoid generated by human peritoneal mesothelium (1090 ng (6h)-1, SEM 86, n = 8)...

CoenzymeQ10 (CoQ10) is used as a food supplement and as an ethical drug because of its antioxidant functions and key role in mitochondrial bioenergetics. In this study, the effects of CoQ10 on blood biochemistry and malondialdehyde (MDA) levels in rats were investigated. Ten male Wistar rats ages ranging between 7 and 8 weeks were used. All animals were kept under the same condition and were gi...