The activity of dopamine (DA)-containing neurons in the ventral tegmental area (VTA) is a key mechanism in mesolimbic reward processing that has modulatory effects on different diencephalic structures like hippocampus (HIP), and receives inhibitory feedback and excitatory feed forward control. In addition, within the hippocampus, DA receptors are mostly located in the dorsal part (CA1) and dopa...

The effects of captopril and Ang II on morphine-induced conditioned place preference (CPP) and morphine self-administration in male Wistar rat were investigated. In CPP experiment, injection of captopril before test significantly decreased the difference of the time spent in compartment A between pre- and post-conditioning compared to morphine group. In self- administration experiment number of...

Obesity is linked to poorer cognitive performance, both of which may result from eating high-fat foods during development. In the present study, preand periadolescent (postnatal days 21 to 40) male rats were fed high fat (HF), high sugar (HS), or rodent chow (Chow) diets. After conditioning for 16 days with either Cheetos (high-fat) or Froot Loops (high-sugar) unconditioned stimuli (US) on one ...

The therapeutic properties of cannabinoids have been well demonstrated but are overshadowed by such adverse effects as cognitive and motor dysfunction, as well as their potential for addiction. Recent research on the natural lipid ligands of cannabinoid receptors, also known as endocannabinoids, has shed light on the mechanisms of intracellular transport of the endocannabinoid anandamide by fat...

Neural systems mediating motivation and reward have been well described in mammalian model systems, especially with reference to reward properties of drugs of abuse. Far less is known of the neural mechanisms underlying motivation and reward in non-mammals. The behavioral procedure conditioned place preference (CPP) is often used to quantify reward properties of psychoactive drugs. The indirect...

Experiment 1: It is well known that the social context powerfully influences behaviour. Here we examine whether it also influences drug-seeking. Further, acamprosate and naloxone have been discussed to affect different types of craving: acamprosate was reported to affect withdrawalcraving, while naloxone affects reward-craving. Conditioned drug-seeking was modelled using the conditioned place p...

Conditioned place preference (CPP) is a commonly used model to detect rewarding effect of drugs. To observe the effect of peripheral electric stimulation (PES) on morphine-induced CPP, we trained the rats with morphine in a CPP paradigm. Twelve hours before the testing phase, rats were given PES via stainless-steel needles with frequencies of 2, 100, or 2/100 Hz, respectively. PES of 2 and 2/10...

background: nicotine can activate dopaminergic neurons within the ventral tegmental area (vta). however, there is no evidence about complete inhibition of vta on nicotine reinforcement. methods: in the present study, we used conditioned-place preference (cpp) method to study the effect of transient inhibition of left and/or right side of the vta by lidocaine on nicotine reward properties. male ...

M1 muscarinic receptor has been shown to be involved in cognitive functions of the brain. Conditioned place preference (CPP) paradigm involves memory for the association between environmental stimuli and the rewarding properties produced by a treatment. Using a balanced CPP design, we studied the possible involvement of M1 muscarinic receptors on the acquisition, expression and consolidation of...

The influence of adenosine receptor agonists and antagonists on cocaine--induced conditioned place preference (CPP) was examined in male Wistar rats. Adenosine receptor agonists, when given alone, induced place preference in some dose ranges, and it seems that adenosine A1 and A2 receptors might be involved in this reaction. All adenosine receptor agonists: 2-p-(2-carboxyethyl)phenethylamino-5'...