An efficient method for the C4-regiocontrolled C-H functionalization of coumarins to enable facile oxidative cross-couplings with simple arene components is disclosed.

Mosquito repellent plants are used in the rural areas of Zimbabwe despite the fact that very few of them have been biologically evaluated. Leaves of the plant Lippia javanica, were collected from Mumurwi village, Zimbabwe and evaluated for repellency against laboratory reared Aedes aegypti mosquitoes. Major plant compounds were identified using Thin Layer Chromatography (TLC) and Mass Spectrome...

One-pot reactions leading to highly functionalized coumarins have been developed via a Pd(II)-catalyzed dehydrogenation-oxidative Heck-cyclization process.

A newly found reaction for the synthesis of 3,4-disubstituted 1-hydroxy-pyrrolidine-2,5-diones from 3-substituted coumarins and nitromethane has been elaborated. The reaction involved a simple and convenient experimental procedure. The applicability of the rearrangement reaction is determined.