A green and efficient one-pot synthesis of benzylamino coumarin derivatives was conducted by a three-component condensation of 4-hydroxycoumarin, cyclic secondary amine, and aromatic aldehyde in the presence of CuO nanoparticles (NPs) as a heterogeneous catalyst in water at room temperature. 

silica-bonded n-propyldiethylenetriamine sulfamic acid (sbpdsa) was found as an efficient solid acid for the synthesis of coumarins. coumarin derivatives were obtained via the pechmann condensation reaction of phenols and β-keto-esters at 80 oc under solvent-free conditions. also, biscoumarins were obtained via the condensation of aldehydes and 4-hydroxycoumarin in water at reflux conditions. t...

The title compound, C(21)H(19)ClF(3)N(3)O(2), has a structure related to other coumarin derivatives that have been used as fluorescent probes of metal ions. The dihedral angle between the coumarin ring system and the chlorobenzene ring is 42.99 (9)°. Intra-molecular hydrogen bonding occurs via N-H⋯O and N-H⋯Cl inter-actions, generating S(7) and S(5) rings, respectively. The crystal packing is s...

Cytochrome P450 (P450) 2A6 is an important human enzyme involved in the metabolism of many xenobiotic chemicals including coumarin, indole, nicotine, and carcinogenic nitrosamines. A combination of random mutagenesis and high-throughput screening was used in the analysis of P450 2A6, utilizing a fluorescent coumarin 7-hydroxylation assay. The steady-state kinetic parameters (k(cat) and Km) for ...

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a simple and fast technique for the analysis of large biomolecules but is not suitable for the detection of low molecular weight molecules and compounds, such as flavonoids and phenylpropanoids, mainly due to the lack of an appropriate matrix. Flavonoids and phenylpropanoids, such as coumarin and its ...

No definitive recommendation is available concerning optimal antithrombotic therapy in pregnant women with a mechanical heart valve. The purpose of the current study was to evaluate the clinical results of nadroparin treatment with respect to pregnancy outcome and maternal complications. From 1997 to 2005, 31 pregnancies were reviewed in 25 women. Nadroparin (7,500 U, twice daily) was used in 2...

Benzeneboronate of catecholic carboxyl methyl esters, N-acetyldopamine, coumarin and catechol estrogens were prepared as crystalline derivatives in high yield. Related catechol compounds with extra polar functional group(s) (OH, NH2) do not form or only partially form unstable cyclic boronate derivatives.

P . R o d i g h i e r o , A . G u i o t t o * , P . M a n z i n i , a n d G . P a s t o r i n i Ist ituto di Chimica Farmaceutica dell 'Universita di Padova , Centro di Studio della Chimica del Farmaco e dei Prodott i Bio logicamente attivi del C N R , V ia Marzolo 5, 1-35100 Padova , I taly Z. Naturforsch. 34b , 1010-1014 (1979); received February 19, 1979 Isoponcimarin, Isomeranzin, Dihydroor...