We tested the hypothesis, motivated in part by a coordinated computational cough network model, that alterations of mean systemic arterial blood pressure (BP) influence the excitability and motor pattern of cough. Model simulations predicted suppression of coughing by stimulation of arterial baroreceptors. In vivo experiments were conducted on anesthetized spontaneously breathing cats. Cough wa...

PURPOSE The present study aimed to examine the age and gender distributions among chronic cough patients referred to a tertiary cough clinic in Korea, and to investigate clinical factors related to the demographic findings. METHODS Study participants were unselectively recruited from adult chronic cough patients who attended the cough clinic for the first time during one year. To validate the...

In adults, cough sensitivity is influenced by gender and is heightened in those with non-productive cough. This study examined if cough sensitivity is (i) altered in children with asthma, recurrent cough, and cystic fibrosis and (ii) influenced by age, gender, or forced expiratory volume in one second (FEV1). Cough sensitivity to capsaicin and spirometry were performed on 209 children grouped b...

Cough is frequently self-limiting, but may persist longer in certain individuals. Most of previous studies on the epidemiology of chronic cough have only measured period prevalence, and thus have afforded limited information on the burden and natural course. We aimed to investigate the epidemiology of chronic cough by using a point prevalence measure in a large-scale general population.We analy...

BACKGROUND Cough is a common presenting symptom in patients with Idiopathic Pulmonary Fibrosis (IPF). This study measured cough rates in IPF patients and investigated the association between cough and measures of health related quality of life and subjective cough assessments. In addition, IPF cough rates were related to measures of physiological disease severity and compared to cough rates in ...

BACKGROUND Cough is one of the main symptoms of advanced lung disease. However, the efficacy of currently available treatment remains unsatisfactory. Research into the new antitussives requires an objective assessment of cough. METHODS The aim of the study was to test the feasibility of a new automatic portable cough analyser and assess the correlation between subjective and objective evaluat...

Post-infectious cough is a common diagnosis in people with chronic cough. However, the specific infectious aetiology and cough mechanisms are seldom identified.We report a case of chronic cough after Mycoplasma pneumoniae lower respiratory tract infection with extrathoracic airway hyperresponsiveness as the cough mechanism. Extrathoracic airway hyperresponsiveness may be a common mechanism in p...

203 Undoubtedly, cough is one of the most common symptoms that make people visit physicians for its treatment. It is also apparent that management of chronic cough is not so simple. Underlying causative diseases are diverse, pathogenic mechanism is not clear, and patients' complaints from personal subjective feelings often make physicians even more frustrated. Furthermore , some patients fail t...

OBJECTIVE To investigate the changing patterns of the spectrum and frequency of causes for chronic cough, and to explore its clinical implications. METHODS Nine hundred and forty patients consecutively referred to Department of Respiratory Medicine for evaluation of chronic cough between January 2004 and December 2008 were collected and divided into 5 groups by periods of 5 years. The causes ...